BX LAB PRODUCT CATEGORY
Coupling Activators
Quick view. Activators for phosphoramidite coupling cycles, including tetrazole- and imidazole-based reagents used in oligonucleotide synthesis. This category currently includes 3 products. Coupling activators promote reaction of a phosphoramidite with the growing oligonucleotide chain in DNA, RNA and modified-monomer synthesis.
Category guide
Coupling activators promote reaction of a phosphoramidite with the growing oligonucleotide chain in DNA, RNA and modified-monomer synthesis.
Match acidity, acetonitrile solubility, activation speed and concentration to the monomer set, synthesizer and target sequence.
Control water content and solution age, then compare full-length yield, deletion products and side reactions in a representative coupling study.
Product-family considerations
- Activator choice can improve difficult couplings and help balance conversion against acid-driven side reactions.
- Dissolution behavior and acidity profiles allow method developers to match the activator to the monomer set and synthesizer platform.
- Overly acidic or mismatched activators may increase detritylation-related side products, dimer formation or n+1 impurities.
- Concentration, water content, reagent age and amidite compatibility should be controlled in routine production methods.
Category literature
These publications provide background for the Coupling Activators product family. Individual product pages only show additional product- or feature-relevant references.
Selection checklist
| Exact identity | Match the canonical name with a CAS number, structure, SMILES or drawing; confirm stereochemistry, protecting groups and salt form where applicable. |
|---|---|
| Specification | Define target purity, analytical method, water or residual-solvent concerns and any application-specific acceptance limits. |
| Workflow fit | Share the reaction, enzyme, sequence, solvent system, support or analytical method used to evaluate compatibility. |
| Supply need | Provide initial quantity, expected future scale, packaging preference, timeline and documentation requirements. |
3 products
≥97% · CAS: 1122-28-7
BX-CA-00355-Benzylthio-1H-tetrazole (BTT)≥98% · CAS: 21871-47-6
BX-CA-00365-Ethylthio-1H-tetrazole (ETT)Specification on request · CAS: 89797-68-2
BX-CA-0037Frequently asked questions
What are typical uses for Coupling Activators?
Coupling activators promote reaction of a phosphoramidite with the growing oligonucleotide chain in DNA, RNA and modified-monomer synthesis.
What should be confirmed before ordering Coupling Activators?
Match acidity, acetonitrile solubility, activation speed and concentration to the monomer set, synthesizer and target sequence.
Are custom quantities or related analogs available?
BX Lab reviews custom package sizes, catalog-adjacent analogs and research-use custom synthesis requests against the target structure, purity, scale and timeline.
Need help selecting a product?
Tell our scientists about your target chemistry, workflow, required purity and scale. We can help identify a catalog product, related analog or custom route.