Sugars
1,2-dideoxy ribofuranose
Quick view. We supply 1,2-dideoxy ribofuranose as a protected or deoxygenated ribofuranose sugar building block for nucleoside and medicinal chemistry synthesis. CAS 91547-59-0. Catalog target purity: ≥98%.
Product profile
1,2-dideoxy ribofuranose is classified as nucleoside or protected nucleoside intermediate (Formula C5H10O3; molecular weight 118.13).
1,2-dideoxy ribofuranose — 1,4-Anhydro-2-deoxy-D-erythro-pentitol was used as a reactant in the study of simple fluorescent pyrimidine analogs that detect the presence of abasic sites in DNA.
For 1,2-dideoxy ribofuranose, polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
Names and search terms
Confirmed or normalized name variants
- 1,2-DIDEOXY-D-RIBOSE
- 1,2-Dideoxy-D-ribofuranose
- 1,4-Anhydro-2-deoxy-D-ribitol
- 1,4-ANHYDRO-D-ERYTHRO-PENTITOL
- 1,4-Anhydro-2-deoxy-D-erythro-pentitol
- D-erythro-Pentitol, 1,4-anhydro-2-deoxy-
- (2R,3S)-2-(Hydroxymethyl)tetrahydrofuran-3-ol
- 1,2-Dideoxy-D-ribose (1,4-anhydro-D-erythro-pentitol)
Useful catalog search terms
- CAS 91547-59-0
- Nucleoside or protected nucleoside intermediate
- Sugars
Physicochemical data
| Boiling point | 105-105 °C(Press: 0.02 Torr) |
|---|---|
| Density | 1.239±0.06 g/cm3(Predicted) |
| pKa | 14.25±0.40(Predicted) |
| InChI | InChI=1S/C5H10O3/c6-3-5-4(7)1-2-8-5/h4-7H,1-3H2/t4-,5+/m0/s |
| InChIKey | NSMOSDAEGJTOIQ-CRCLSJGQSA-N |
| SMILES | C1CO[C@@H]([C@H]1O)CO |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 1,2-dideoxy ribofuranose can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
These points describe 1,2-dideoxy ribofuranose or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 1,2-dideoxy ribofuranose be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-SUGA-0001 and CAS 91547-59-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Sugars product family and its named chemistry.