Halogenated Nucleosides
2',3'-Dideoxy-3'-fluoroadenosine
Quick view. We supply 2',3'-Dideoxy-3'-fluoroadenosine as a halogenated nucleoside analog for modified nucleoside, antiviral/antimetabolite and oligonucleotide precursor research. CAS 87418-35-7. Catalog target purity: Specification on request.
Product profile
2',3'-Dideoxy-3'-fluoroadenosine is classified as nucleoside or protected nucleoside intermediate (Formula C10H12FN5O2; molecular weight 253.23).
2',3'-Dideoxy-3'-fluoroadenosine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2',3'-Dideoxy-3'-fluoroadenosine, polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
Names and search terms
Confirmed or normalized name variants
- 9-(3-Fluoro-2,3-dideoxy-beta-D-erythro-pentofuranosyl)adenine
- 3'-Fluoro-2',3'-dideoxyadenosine
- 2’,3’-Dideoxy-3’-fluoroadenosine, 3’-F-ddA
- 2’,3’-Dideoxy-3’-fluoroadenosine, 3’-F-ddA, anti-HIV agent
Useful catalog search terms
- CAS 87418-35-7
- Nucleoside or protected nucleoside intermediate
- Halogenated Nucleosides
Physicochemical data
| InChI | InChI=1S/C10H12FN5O2/c11-5-1-7(18-6(5)2-17)16-4-15-8-9(12)13-3-14-10(8)16/h3-7,17H,1-2H2,(H2,12,13,14)/t5-,6+,7+/m0/s |
|---|---|
| InChIKey | CTDUJDNZPPZTAV-RRKCRQDMSA-N |
| SMILES | C1[C@@H]([C@H](O[C@H]1N2C=NC3=C(N=CN=C32)N)CO)F |
| Melting point | 188-190 °C |
| Boiling point | 541.3±60.0 °C(Predicted) |
| Density | 1.85±0.1 g/cm3(Predicted) |
| pKa | 14.44±0.10(Predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2',3'-Dideoxy-3'-fluoroadenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2',3'-Dideoxy-3'-fluoroadenosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-HN-0260 and CAS 87418-35-7, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry.