Halogenated Nucleosides
2',3'-Dideoxy-3'-fluorocytidine
Quick view. We supply 2',3'-Dideoxy-3'-fluorocytidine as a halogenated nucleoside analog for modified nucleoside, antiviral/antimetabolite and oligonucleotide precursor research. CAS 51246-79-8. Catalog target purity: Specification on request.
Product profile
2',3'-Dideoxy-3'-fluorocytidine is classified as nucleoside or protected nucleoside intermediate (Formula C9H12FN3O3; molecular weight 229.21).
2',3'-Dideoxy-3'-fluorocytidine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2',3'-Dideoxy-3'-fluorocytidine, form: Solid.
Names and search terms
Confirmed or normalized name variants
- Cytidine, 2',3'-dideoxy-3'-fluoro-
- Fddcyd
- 3'-Fddc
- Aids000014
- 3'-Fluoro-2',3'-dideoxycytidine
- 2’,3’-Dideoxy-3’-fluorocytidine, FddC
- 2’,3’-Dideoxy-3’-fluorocytidine, FddC, HIV-1 inhibitor
- 1-(3-fluoro-2,3-dideoxy-β-D-erythro-pentofuranosyl)cytosine
Useful catalog search terms
- CAS 51246-79-8
- Nucleoside or protected nucleoside intermediate
- Halogenated Nucleosides
Physicochemical data
| InChI | InChI=1S/C9H12FN3O3/c10-5-3-8(16-6(5)4-14)13-2-1-7(11)12-9(13)15/h1-2,5-6,8,14H,3-4H2,(H2,11,12,15)/t5-,6+,8+/m0/s |
|---|---|
| InChIKey | HNSUDSIHCJEYQG-SHYZEUOFSA-N |
| SMILES | C1[C@@H]([C@H](O[C@H]1N2C=CC(=NC2=O)N)CO)F |
| Boiling point | 418.0±55.0 °C(Predicted) |
| Density | 1.67±0.1 g/cm3(Predicted) |
| pKa | 14.44±0.10(Predicted) |
| Form | Solid |
| Color | Off-white to light yellow |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2',3'-Dideoxy-3'-fluorocytidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2',3'-Dideoxy-3'-fluorocytidine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-HN-0243 and CAS 51246-79-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry.