Other Modified Nucleosides
2',3'-O-Me-rA
Quick view. We supply 2',3'-O-Me-rA as a dimethylated adenosine analog for methylated RNA model systems and nucleoside chemistry. CAS 20649-46-1. Catalog target purity: Specification on request.
Product profile
2',3'-O-Me-rA is classified as nucleoside or protected nucleoside intermediate (Formula C12H17N5O4; molecular weight 295.29).
2',3'-O-Me-rA can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2',3'-O-Me-rA, reported solubility: DMSO (Slightly), Methanol (Slightly). Storage: Hygroscopic, Refrigerator, under inert atmosphere.
Names and search terms
Confirmed or normalized name variants
- 2',3'-DIMETHOXYADENOSINE
- 2',3'-Di-O-methyladenosine
- Adenosine, 2',3'-di-O-methyl-
- Adenosine,2',3'-di-O-Methyl-(8CI,9CI)
- (2R,3R,4S,5R)-2-(6-Amino-9H-purin-9-yl)-5-(hydroxymethyl)-3,4-dimethoxyoxolane-3,4-diol (non-preferred name)
Useful catalog search terms
- CAS 20649-46-1
- Nucleoside or protected nucleoside intermediate
- Other Modified Nucleosides
Physicochemical data
| Melting point | 167-172°C |
|---|---|
| Boiling point | 553.4±60.0 °C(Predicted) |
| Density | 1.66±0.1 g/cm3(Predicted) |
| pKa | 14.44±0.10(Predicted) |
| Form | Solid |
| Color | White |
| InChI | InChI=1S/C12H17N5O6/c1-21-11(19)6(3-18)23-10(12(11,20)22-2)17-5-16-7-8(13)14-4-15-9(7)17/h4-6,10,18-20H,3H2,1-2H3,(H2,13,14,15)/t6-,10-,11+,12-/m1/s |
| InChIKey | VEUFBAPMMDFOOF-IJJXPJNWSA-N |
| SMILES | CO[C@]1([C@H](O[C@H]([C@@]1(O)OC)N2C=NC3=C(N=CN=C32)N)CO)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 3′-O-methylation provides a defined blocked ribose terminus and is analytically distinguishable from the corresponding 2′-O-methyl isomer.
Method limitations
- The 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
These points describe 2',3'-O-Me-rA or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2',3'-O-Me-rA be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0158 and CAS 20649-46-1, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Other Modified Nucleosides product family and its named chemistry.