Halogenated Nucleosides
2'-Deoxy-5-fluorouridine
Quick view. We supply 2'-Deoxy-5-fluorouridine as a halogenated nucleoside analog for modified nucleoside, antiviral/antimetabolite and oligonucleotide precursor research. CAS 50-91-9. Catalog target purity: Specification on request.
Product profile
2'-Deoxy-5-fluorouridine is classified as nucleoside or protected nucleoside intermediate (Formula C9H11FN2O5; molecular weight 246.19).
2'-Deoxy-5-fluorouridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-Deoxy-5-fluorouridine, reported solubility: Soluble to 100 mM in water and to 100 mM in DMSO. Storage: 2-8°C.
Names and search terms
Confirmed or normalized name variants
- floxuridine
- 1-(2-DEOXY-BETA-D-RIBOFURANOSYL)-5-FLUOROURACIL
- 5-FDU
- 5-FLOXURIDINE
- 5-FLUORO-2'-DEOXY-BETA-URIDINE
- (+)-5-FLUORO-2'-DEOXYURIDINE
- (+)-5-FLUORODEOXYURIDINE
- FDURD
Useful catalog search terms
- CAS 50-91-9
- Nucleoside or protected nucleoside intermediate
- Halogenated Nucleosides
Physicochemical data
| InChI | 1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s |
|---|---|
| InChIKey | ODKNJVUHOIMIIZ-GFCOJPQKSA-N |
| SMILES | OC[C@H]1O[C@H](C[C@@H]1O)N2C=C(F)C(=O)NC2=O |
| Melting point | 148 °C(lit.) |
| Boiling point | 150 °C |
| Density | 1.3751 (estimate) |
| pKa | pKa 7.44 (Uncertain) |
| Form | Powder |
| Color | White to almost white |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2'-Deoxy-5-fluorouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-Deoxy-5-fluorouridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-HN-0242 and CAS 50-91-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry.