Modified Nucleosides
2'-Deoxy-N1-methylguanosine
Quick view. We supply 2'-Deoxy-N1-methylguanosine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 5132-79-6. Catalog target purity: Specification on request.
Product profile
2'-Deoxy-N1-methylguanosine is classified as nucleoside or protected nucleoside intermediate (Formula C11H15N5O4; molecular weight 281.27).
2'-Deoxy-N1-methylguanosine — N1-Methyl-2’-deoxyguanosine is a model for alkylation of DNA. Also, it is formed from the reaction of 2’-Deoxyguanosine with N-Nitroso-N-methyl-N’-phenylurea in methanol.
For 2'-Deoxy-N1-methylguanosine, reported solubility: DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly, Heated). Storage: Hygroscopic, Refrigerator, under inert atmosphere.
Names and search terms
Confirmed or normalized name variants
- 9-(2-Deoxypentofuranosyl)-2-imino-1-methyl-1,2,3,9-tetrahydro-6H-purin-6-one
- N1-METHYL-2'-DEOXYGUANOSINE
- Guanosine, 2'-deoxy-1-methyl-
Useful catalog search terms
- CAS 5132-79-6
- Nucleoside or protected nucleoside intermediate
- Modified Nucleosides
Physicochemical data
| InChI | InChI=1S/C11H15N5O4/c1-15-10(19)8-9(14-11(15)12)16(4-13-8)7-2-5(18)6(3-17)20-7/h4-7,17-18H,2-3H2,1H3,(H2,12,14) |
|---|---|
| InChIKey | VJSHSPNFYFRXGN-UHFFFAOYSA-N |
| SMILES | Cn1c(=N)[nH]c2c(ncn2C2CC(O)C(CO)O2)c1=O |
| Melting point | >227°C (dec.) |
| Boiling point | 690.7±65.0 °C(Predicted) |
| Density | 1.88±0.1 g/cm3(Predicted) |
| pKa | 13.86±0.60(Predicted) |
| Form | Solid |
| Color | White to Off-White |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 2'-Deoxy-N1-methylguanosine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
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Frequently asked questions
Can the package size for 2'-Deoxy-N1-methylguanosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0576 and CAS 5132-79-6, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry.