2'-O-Me Nucleosides
2-Amino-2'-O-methyladenosine
Quick view. A 2-amino-2'-O-methyladenosine nucleoside building block for nucleoside and oligonucleotide synthesis research. CAS 80791-87-3. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
2-Amino-2'-O-methyladenosine is classified as 2'-o-me nucleosides (Formula C11H16N6O4; molecular weight 296.28).
2-Amino-2'-O-methyladenosine — Modified purine nucleoside building block for nucleoside and oligonucleotide synthesis research.
For 2-Amino-2'-O-methyladenosine, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Confirmed or normalized name variants
- 2'-O-Me-2-NH2-rA
- 2'-O-methyl-2,6-diaminopurine riboside
Useful catalog search terms
- CAS 80791-87-3
Physicochemical data
| InChIKey | JLWUWXCKSOIFPS-KQYNXXCUSA-N |
|---|---|
| Nucleobase | 2,6-Diaminopurine |
| Sugar modification | 2'-O-methyl |
| InChI | InChI=1S/C11H16N6O4/c1-20-7-6(19)4(2-18)21-10(7)17-3-14-5-8(12)15-11(13)16-9(5)17/h3-4,6-7,10,18-19H,2H2,1H3,(H4,12,13,15,16)/t4-,6-,7-,10-/m1/s1 |
| SMILES | CO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=NC3=C(N=C(N=C32)N)N)CO)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 2-Amino-2'-O-methyladenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2-Amino-2'-O-methyladenosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMN-0002 and CAS 80791-87-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.