Base-protected Nucleosides
2'-O-Me-rA(Bz)
Quick view. We supply 2'-O-Me-rA(Bz) as a protected 2'-O-methyl nucleoside precursor for modified RNA and oligonucleotide monomer synthesis. CAS 85079-00-1. Catalog target purity: Specification on request.
Product profile
2'-O-Me-rA(Bz) is classified as nucleoside or protected nucleoside intermediate (Formula C18H19N5O5; molecular weight 385.37).
2'-O-Me-rA(Bz) — N6-Benzoyl-2''-o-methyl-adenosine is used in production of oligonucleotide from bicyclic phosphoramidite.
For 2'-O-Me-rA(Bz), form: Solid.
Names and search terms
Confirmed or normalized name variants
- Bz-2'-OMe-A
- N6-Bz-2'-OMe-A
- N6-Bz-2'-O-Me-Ar
- N6-Benzoyl-2'-OMe-adenosine
- N6-Benzoyl-2'-O-Methyl-adenosine
- N6-Benzoyl-2'-O-Methyladdenosine
- Adenosine, N-benzoyl-2'-O-Methyl-
Useful catalog search terms
- CAS 85079-00-1
- Nucleoside or protected nucleoside intermediate
- 2'-O-methyl modification
- Base-protected Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-O-methyl modification |
|---|---|
| Density | 1.59±0.1 g/cm3(Predicted) |
| pKa | 7.87±0.43(Predicted) |
| Form | Solid |
| Color | White to off-white |
| SMILES | OC[C@H]1O[C@@H](N2C3C(=C(N=CN=3)NC(=O)C3=CC=CC=C3)N=C2)[C@H](OC)[C@@H]1O |
| InChIKey | PHFHSPQCDRKMQJ-XWXWGSFUSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 2'-O-Me-rA(Bz) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 2'-O-Me-rA(Bz) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-O-Me-rA(Bz) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0107 and CAS 85079-00-1, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Base-protected Nucleosides product family and its named chemistry.