Base-protected Nucleosides
2'-O-Me-rC(Bz)
Quick view. We supply 2'-O-Me-rC(Bz) as a protected 2'-O-methyl nucleoside precursor for modified RNA and oligonucleotide monomer synthesis. CAS 52571-45-6. Catalog target purity: Specification on request.
Product profile
2'-O-Me-rC(Bz) is classified as nucleoside or protected nucleoside intermediate (Formula C17H19N3O6; molecular weight 361.35).
2'-O-Me-rC(Bz) — N4-Benzoyl-2’-O-methylcytidine is a key building block in the block synthesis strategy of tRNA fragments.
For 2'-O-Me-rC(Bz), storage: Sealed in dry,2-8°C. Form: Powder.
Names and search terms
Confirmed or normalized name variants
- Bz-2'-OMe-C
- 5-Iodo-2&rsquo
- N4-Bz-2'-OMe-C
- N4-BENZOYL-2'
- N4-Bz-2'-O-Me-Cr
- -O-METHYLCYTIDINE
- -deoxy-a-cytidine
- N-Benzoyl-2'-O-methylcytidine
Useful catalog search terms
- CAS 52571-45-6
- Nucleoside or protected nucleoside intermediate
- 2'-O-methyl modification
- Base-protected Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-O-methyl modification |
|---|---|
| Melting point | 174-175℃ |
| Density | 1.49 |
| pKa | 8.59±0.20(Predicted) |
| Form | Powder |
| Color | White to Pale Yellow |
| InChI | InChI=1S/C17H19N3O6/c1-25-14-13(22)11(9-21)26-16(14)20-8-7-12(19-17(20)24)18-15(23)10-5-3-2-4-6-10/h2-8,11,13-14,16,21-22H,9H2,1H3,(H,18,19,23,24)/t11-,13-,14-,16-/m1/s |
| InChIKey | LIZIIHWLABYQKD-XKVFNRALSA-N |
| SMILES | CO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=CC(=NC2=O)NC(=O)C3=CC=CC=C3)CO)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 2'-O-Me-rC(Bz) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 2'-O-Me-rC(Bz) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-O-Me-rC(Bz) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0101 and CAS 52571-45-6, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Base-protected Nucleosides product family and its named chemistry.