Reverse Phosphoramidites
2'-O-MOE-G(ibu) Reverse Phosphoramidite
Quick view. We supply 2'-O-MOE-G(ibu) Reverse Phosphoramidite as a reverse-direction 2'-O-MOE guanosine monomer for synthesis of MOE-modified antisense oligonucleotides. CAS 725223-44-9. Catalog target purity: Specification on request.
Structure and identity
The structure drawing for this item is being finalized. Use the CAS number and machine-readable identifiers below to confirm the requested protecting groups, stereochemistry, salt or counterion and hydration state before ordering.
CAS, molecular formula, SMILES or InChI data are shown below when available.
We withhold a drawing when a related compound, alternate salt or incompletely specified stereoisomer could be mistaken for the requested material.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
2'-O-MOE-G(ibu) Reverse Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block (Formula C47H60N7O10P; molecular weight 913.99).
2'-O-MOE-G(ibu) Reverse Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
For 2'-O-MOE-G(ibu) Reverse Phosphoramidite, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- Rev2'-O-MOE-G(iBu)-5'-amidite
Useful catalog search terms
- CAS 725223-44-9
- Protected oligonucleotide phosphoramidite building block
- 2'-O-MOE modification
- phosphoramidite coupling group
- Reverse Phosphoramidites
Physicochemical data
| Key chemistry motifs | 2'-O-MOE modification; phosphoramidite coupling group |
|---|
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 2'-O-MOE-G(ibu) Reverse Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-O-MOE-G(ibu) Reverse Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-RP-0022 and CAS 725223-44-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Reverse Phosphoramidites product family and its named chemistry.