Base-protected Nucleosides
2'-O-MOE-rA(Bz)
Quick view. We supply 2'-O-MOE-rA(Bz) as a base- or sugar-protected nucleoside intermediate for nucleoside, nucleotide and oligonucleotide building-block synthesis. CAS 333335-93-6. Catalog target purity: Specification on request.
Product profile
2'-O-MOE-rA(Bz) is classified as nucleoside or protected nucleoside intermediate (Formula C20H23N5O6; molecular weight 429.43).
2'-O-MOE-rA(Bz) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-O-MOE-rA(Bz), mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- N6-Bz-2'-O-MOE-Ar
- N6-Bz-2'-MOE-Adenosine
- N6-Benzoyl-2'-O-Methoxyethyladdenosine
- 2'-O-methoxyethyl- N6-benzoyl -adenosine
- N6-Benzoyl-2'-O-(2-methoxyethyl)adenosine
- 2'-O-(2-methoxyethyl)-N6-benzoyl-adenosine
- Adenosine, N-benzoyl-2'-O-(2-methoxyethyl)-
- N-Benzoyl-2'-O-(2-methoxyethyl)adenosine
Useful catalog search terms
- CAS 333335-93-6
- Nucleoside or protected nucleoside intermediate
- 2'-O-MOE modification
- Base-protected Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-O-MOE modification |
|---|---|
| Density | 1.53±0.1 g/cm3(Predicted) |
| pKa | 13.15±0.70(Predicted) |
| InChI | InChI=1S/C20H23N5O6/c1-29-7-8-30-16-15(27)13(9-26)31-20(16)25-11-23-14-17(21-10-22-18(14)25)24-19(28)12-5-3-2-4-6-12/h2-6,10-11,13,15-16,20,26-27H,7-9H2,1H3,(H,21,22,24,28)/t13-,15-,16-,20-/m1/s |
| InChIKey | RUFJMCSVNNGZFB-KHTYJDQRSA-N |
| SMILES | COCCO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)CO)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 2'-O-MOE-rA(Bz) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-O-MOE-rA(Bz) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0082 and CAS 333335-93-6, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Base-protected Nucleosides product family and its named chemistry.