2'-O-MOE Nucleosides
2'-O-MOE-rC
Quick view. We supply 2'-O-MOE-rC as a methoxyethyl cytidine nucleoside for MOE oligonucleotide chemistry. CAS 223777-16-0. Catalog target purity: Specification on request.
Product profile
2'-O-MOE-rC is classified as nucleoside or protected nucleoside intermediate (Formula C12H19N3O6; molecular weight 301.3).
2'-O-MOE-rC — A cytidine derivative as building blocks for cross-linking oligonucleotides.
For 2'-O-MOE-rC, reported solubility: DMSO: 250 mg/mL (829.74 mM). Storage: Sealed in dry,2-8°C.
Names and search terms
Confirmed or normalized name variants
- 2'-O-MOE Cytidine
- 2'-O-(2-Methoxyethyl)cytidine
- Cytidine, 2'-O-(2-methoxyethyl)-
- 4-AMINO-1-[4-HYDROXY-5-(HYDROXYMETHYL)-3-(2-METHOXYETHOXY)OXOLAN-2-YL]PYRIMIDIN-2-ONE
Useful catalog search terms
- CAS 223777-16-0
- Nucleoside or protected nucleoside intermediate
- 2'-O-MOE modification
- 2'-O-MOE Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-O-MOE modification |
|---|---|
| Boiling point | 535.3±60.0 °C(Predicted) |
| Density | 1.57±0.1 g/cm3(Predicted) |
| pKa | 13.36±0.70(Predicted) |
| Form | Solid |
| Color | White to off-white |
| SMILES | OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)[C@H](OCCOC)[C@@H]1O |
| InChI | InChI=1S/C12H19N3O6/c1-19-4-5-20-10-9(17)7(6-16)21-11(10)15-3-2-8(13)14-12(15)18/h2-3,7,9-11,16-17H,4-6H2,1H3,(H2,13,14,18)/t7-,9-,10-,11-/m1/s |
| InChIKey | YKOGMMXZKKVMBT-QCNRFFRDSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 2'-O-MOE-rC can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 2'-O-MOE-rC or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
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2'-O-MOE Nucleosides · CAS: 473278-54-5
BX-MN-01692'-O-MOE-rA
2'-O-MOE Nucleosides · CAS: 168427-74-5
BX-MN-01712'-O-MOE-rU
2'-O-MOE Nucleosides · CAS: 223777-15-9
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2'-O-MOE Nucleosides · CAS: 163759-49-7
Frequently asked questions
Can the package size for 2'-O-MOE-rC be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0170 and CAS 223777-16-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-O-MOE Nucleosides product family and its named chemistry.