Base-protected Nucleosides
2'-O-MOE-rG(iBu)
Quick view. We supply 2'-O-MOE-rG(iBu) as a base- or sugar-protected nucleoside intermediate for nucleoside, nucleotide and oligonucleotide building-block synthesis. CAS 440327-50-4. Catalog target purity: Specification on request.
Product profile
2'-O-MOE-rG(iBu) is classified as nucleoside or protected nucleoside intermediate (Formula C17H25N5O7; molecular weight 411.41).
2'-O-MOE-rG(iBu) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-O-MOE-rG(iBu), mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- N2-iBu-2'-O-MOE-Gr
- 2’-MOE-N2-iBu-Guanosine
- N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine
- N2-iso-Butyroyl-2'-O-(2-methoxyethyl)guanosine
- Guanosine, 2'-O-(2-methoxyethyl)-N-(2-methyl-1-oxopropyl)-
- SCHEMBL7068737
Useful catalog search terms
- CAS 440327-50-4
- Nucleoside or protected nucleoside intermediate
- 2'-O-MOE modification
- Base-protected Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-O-MOE modification |
|---|---|
| SMILES | OC[C@H]1O[C@@H](N2C3=C(C(NC(=N3)NC(=O)C(C)C)=O)N=C2)[C@H](OCCOC)[C@@H]1O |
| InChIKey | IZOOGJIUOCHAAY-UBEDBUPSSA-N |
| InChI | InChI=1S/C17H25N5O7/c1-8(2)14(25)20-17-19-13-10(15(26)21-17)18-7-22(13)16-12(28-5-4-27-3)11(24)9(6-23)29-16/h7-9,11-12,16,23-24H,4-6H2,1-3H3,(H2,19,20,21,25,26)/t9-,11-,12-,16-/m1/s |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 2'-O-MOE-rG(iBu) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-O-MOE-rG(iBu) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0081 and CAS 440327-50-4, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Base-protected Nucleosides product family and its named chemistry.