Reverse Phosphoramidites
2'-OMe-G(iBu)-CE-Reverse Phosphoramidite
Quick view. 2'-OMe-G(iBu)-CE-Reverse Phosphoramidite is a protected 2'-O-methyl guanosine building block with 3'-O-DMTr protection, an N2-isobutyryl group and a 5'-cyanoethyl N,N-diisopropyl phosphoramidite. Its constitutional record corresponds to PubChem CID 169548376, with exact stereochemistry controlled by the reviewed supplier InChI. CAS 2721427-31-0. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
2'-OMe-G(iBu)-CE-Reverse Phosphoramidite is classified as protected 2'-o-methyl purine nucleoside reverse phosphoramidite (Formula C45H56N7O9P; molecular weight 869.96).
2'-OMe-G(iBu)-CE-Reverse Phosphoramidite supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 2'-OMe-G(iBu)-CE-Reverse Phosphoramidite, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 3'-O-DMTr-2'-O-Me-G(iBu)-5'-CE-Phosphoramidite
- 3'-DMT-2'-OMe-G(iBu)-CE Reverse
Useful catalog search terms
- CAS 2721427-31-0
- Reverse Phosphoramidites
Physicochemical data
| PubChem CID | 169548376 |
|---|---|
| InChIKey | ZRRIKKNCSIFYAP-MLLDKZSOSA-N |
| Structural features | 3'-O-DMTr; 2'-O-methyl; N2-isobutyryl guanine; 5'-cyanoethyl N,N-diisopropyl phosphoramidite |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 2'-OMe-G(iBu)-CE-Reverse Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
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BX-RP-00023'-O-DMTr-2'-O-MOE-5-Me-rC(Bz)-5'-CE-Phosphoramidite
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BX-RP-00033'-O-DMTr-2'-O-MOE-rA(Bz)-5'-CE-Phosphoramidite
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BX-RP-00043'-O-DMTr-2'-O-MOE-rG(iBu)-5'-CE-Phosphoramidite
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BX-RP-00063'-O-DMTr-2'-O-Me-rU-5'-CE-Phosphoramidite
Reverse Phosphoramidites · CAS: 2721427-32-1
BX-RP-00073'-O-DMTr-2'-dG(dmf)-5'-CE-Phosphoramidite
Reverse Phosphoramidites · CAS: 261728-23-8
Frequently asked questions
Can the package size for 2'-OMe-G(iBu)-CE-Reverse Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-RP-0020 and CAS 2721427-31-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Reverse Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.