Modified Nucleosides
2-Thiouridine
Quick view. We supply 2-thiouridine as a dry sulfur-modified nucleoside for RNA modification, nucleoside-analog and analytical research. CAS 20235-78-3. Catalog target purity: ≥99%.
Product profile
2-Thiouridine is classified as nucleoside or protected nucleoside intermediate (Formula C9H12N2O5S; molecular weight 260.27).
2-Thiouridine — Modified nucleotide, essential for normal cell growth in some bacterial species. This compound is also able to chelate several metal ions.
For 2-Thiouridine, reported solubility: DMSO (Slightly, Heated), Water (Slightly, Heated). Storage: Refrigerator.
Names and search terms
Confirmed or normalized name variants
- 2-Thioxo-2-deoxyuridine
- 2-S-thiouridine
- s2U
- 2-Thio-D-uridine
- Uridine, 2-thio-
- 2-Thioxo-2-deoxouridine
- 1-β-D-Ribofuranosyl-2-thiouracil
- 1-beta-D-Ribofuranosyl-2-thiouracil
Useful catalog search terms
- CAS 20235-78-3
- Nucleoside or protected nucleoside intermediate
- Modified Nucleosides
Physicochemical data
| Base modification | 2-thioxo uracil |
|---|---|
| Supply form | Dry research material |
| InChI | InChI=1S/C9H12N2O5S/c12-3-4-6(14)7(15)8(16-4)11-2-1-5(13)10-9(11)17/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,17)/t4-,6-,7-,8-/m1/s |
| InChIKey | GJTBSTBJLVYKAU-XVFCMESISA-N |
| SMILES | OC[C@H]1O[C@@H](N2C=CC(=O)NC2=S)[C@H](O)[C@@H]1O |
| Melting point | 216-218°C |
| Density | 1.72±0.1 g/cm (20 ºC 760 Torr) |
| pKa | 6.98±0.20(Predicted) |
| Form | Solid |
| Color | White to Off-White |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 2-Thiouridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
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Frequently asked questions
Can the package size for 2-Thiouridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-GSS-0044 and CAS 20235-78-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry.