Halogenated Nucleosides
3'-Deoxy-3'-fluoroguanosine
Quick view. We supply 3'-Deoxy-3'-fluoroguanosine as a halogenated nucleoside analog for modified nucleoside, antiviral/antimetabolite and oligonucleotide precursor research. CAS 123402-21-1. Catalog target purity: ≥95%.
Product profile
3'-Deoxy-3'-fluoroguanosine is classified as nucleoside or protected nucleoside intermediate (Formula C10H12FN5O4; molecular weight 285.23).
3'-Deoxy-3'-fluoroguanosine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 3'-Deoxy-3'-fluoroguanosine, reported solubility: Acetonitrile: Slightly soluble DMSO: Soluble Methanol: Slightly soluble Water: Slightly soluble. Storage: Keep in dark place,Inert atmosphere,2-8°C.
Names and search terms
Confirmed or normalized name variants
- Aids001160
- 3'-f-3'-dG
- 3fluoro-3deoxyguanosine
- Guanosine, 3'-deoxy-3'-fluoro-
- 3fluoro-3deoxyguanosine USP/EP/BP
- 9-[3-Deoxy-3-C-fluoro-β-D-ribofuranosyl]guanine
- 9-[3-DEOXY-3-C-FLUORO-SS-D-RIBOFURANOSYL]GUANINE
- 9-[3-Deoxy-3-C-fluoro-beta-D-ribofuranosyl]guanine
Useful catalog search terms
- CAS 123402-21-1
- Nucleoside or protected nucleoside intermediate
- Halogenated Nucleosides
Physicochemical data
| SMILES | O=C1NC(N)=NC2=C1N=CN2[C@@H]3O[C@H](CO)[C@@H](F)[C@H]3O |
|---|---|
| InChI | InChI=1S/C10H12FN5O4/c11-4-3(1-17)20-9(6(4)18)16-2-13-5-7(16)14-10(12)15-8(5)19/h2-4,6,9,17-18H,1H2,(H3,12,14,15,19)/t3-,4-,6-,9-/m1/s |
| InChIKey | VDOWHLFGBWKXJC-DXTOWSMRSA-N |
| Melting point | 289-291 °C |
| Density | 2.17±0.1 g/cm3(Predicted) |
| Form | Solid |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 3'-Deoxy-3'-fluoroguanosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 3'-Deoxy-3'-fluoroguanosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-HN-0220 and CAS 123402-21-1, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry.