Other Nucleosides
3'-O-azidomethylene-dT
Quick view. We supply 3'-O-azidomethylene-dT as a 3'-blocked thymidine analog for reversible terminator and controlled DNA synthesis workflows. CAS 136041-38-8. Catalog target purity: ≥98%.
Product profile
3'-O-azidomethylene-dT is classified as nucleoside or protected nucleoside intermediate (Formula C11H15N5O5; molecular weight 297.27).
3'-O-azidomethylene-dT can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 3'-O-azidomethylene-dT, copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
Names and search terms
Confirmed or normalized name variants
- 3′-O-Azidomethyl dT
- 3'-O-(Azidomethyl)-2'-deoxythymidine
Useful catalog search terms
- CAS 136041-38-8
- Nucleoside or protected nucleoside intermediate
- azide click handle
- Other Nucleosides
Physicochemical data
| Key chemistry motifs | azide click handle |
|---|
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
These points describe 3'-O-azidomethylene-dT or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
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BX-NDO-00137-Deaza-2'-dG
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Frequently asked questions
Can the package size for 3'-O-azidomethylene-dT be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-NDO-0011 and CAS 136041-38-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 3'-O-azidomethylene-dT or the named structural feature represented by this product.