Protected Nucleosides
3'-O-TBDMS-2'-F-dG(iBu)
Quick view. We supply 3'-O-TBDMS-2'-F-dG(iBu) as a protected 2'-fluoro guanosine building block used upstream of RNA-modification and phosphoramidite synthesis. The 3'-O-TBDMS and nucleobase isobutyryl protections help control selective functionalization during multistep preparation. CAS 2382967-92-0. Catalog target purity: Specification on request.
Product profile
3'-O-TBDMS-2'-F-dG(iBu) is classified as nucleoside or protected nucleoside intermediate.
3'-O-TBDMS-2'-F-dG(iBu) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 3'-O-TBDMS-2'-F-dG(iBu), coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Useful catalog search terms
- CAS 2382967-92-0
- Nucleoside or protected nucleoside intermediate
- TBDMS protection
- 2'-fluoro modification
- Protected Nucleosides
Physicochemical data
| Key chemistry motifs | TBDMS protection; 2'-fluoro modification |
|---|
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 3'-O-TBDMS-2'-F-dG(iBu) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 3'-O-TBDMS-2'-F-dG(iBu) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0067 and CAS 2382967-92-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Protected Nucleosides product family and its named chemistry.