2'-FANA Nucleosides
4'-Azido-2'-deoxy-2'-fluoro-beta-D-arabino ribofuranosyl uracil
Quick view. We supply 4'-Azido-2'-deoxy-2'-fluoro-beta-D-arabino ribofuranosyl uracil as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 173379-73-2. Catalog target purity: Specification on request.
Structure and identity
The structure drawing for this item is being finalized. Use the CAS number and machine-readable identifiers below to confirm the requested protecting groups, stereochemistry, salt or counterion and hydration state before ordering.
CAS, molecular formula, SMILES or InChI data are shown below when available.
We withhold a drawing when a related compound, alternate salt or incompletely specified stereoisomer could be mistaken for the requested material.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
4'-Azido-2'-deoxy-2'-fluoro-beta-D-arabino ribofuranosyl uracil is classified as nucleoside or protected nucleoside intermediate (Formula C9H10FN5O5; molecular weight 287.205).
4'-Azido-2'-deoxy-2'-fluoro-beta-D-arabino ribofuranosyl uracil can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 4'-Azido-2'-deoxy-2'-fluoro-beta-D-arabino ribofuranosyl uracil, copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
Names and search terms
Confirmed or normalized name variants
- 4’-Azido-2’-deoxy-2’-fluoro-β-D-arabinouridine
- 4'-C-Azido-2'-deoxy-2'-fluoro-b-D-arabinouridine
- 4'-Azido-2'-deoxy-2'-fluoro-beta-D-arabinouridine
- 4'-C-azido-2'-deoxy-2'-fluoro-beta-D-arabinouridine
- 4'-Azido-2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl uracil
- 2,4(1H,3H)-PyriMidinedione, 1-[4-C-azido-2-deoxy-2-fluoro-b-D-arabinofuranosyl]-
- 1-[4-C-Azido-2-deoxy-2-fluoro-beta-D-arabinofuranosyl]-2,4(1H,3H)-pyrimidinedione
Useful catalog search terms
- CAS 173379-73-2
- Nucleoside or protected nucleoside intermediate
- 2'-fluoro modification
- azide click handle
- 2'-FANA Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-fluoro modification; azide click handle |
|---|---|
| SMILES | N([C@]1([C@H]([C@H](F)[C@H](N2C=CC(=O)NC2=O)O1)O)CO)=[N+]=[N-] |&1:1,2,3,5,r| |
| InChI | InChI=1/C9H10FN5O5/c10-5-6(18)9(3-16,13-14-11)20-7(5)15-2-1-4(17)12-8(15)19/h1-2,5-7,16,18H,3H2,(H,12,17,19)/t5-,6-,7+,9+/s |
| InChIKey | SNWCOSVWPQSOEU-BODDTQOYNA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 4'-Azido-2'-deoxy-2'-fluoro-beta-D-arabino ribofuranosyl uracil or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 4'-Azido-2'-deoxy-2'-fluoro-beta-D-arabino ribofuranosyl uracil be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2FAN-0030 and CAS 173379-73-2, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 4'-Azido-2'-deoxy-2'-fluoro-beta-D-arabino ribofuranosyl uracil or the named structural feature represented by this product.