2'-F Nucleosides
4'-Azido-2'-deoxy-2'-fluoroaracytidine
Quick view. We supply 4'-Azido-2'-deoxy-2'-fluoroaracytidine as a 2'-fluoro nucleoside for modified nucleotide, amidite and nucleoside analog synthesis. CAS 1011529-10-4. Catalog target purity: Specification on request.
Product profile
4'-Azido-2'-deoxy-2'-fluoroaracytidine is classified as nucleoside or protected nucleoside intermediate (Formula C9H11FN6O4; molecular weight 286.22).
4'-Azido-2'-deoxy-2'-fluoroaracytidine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 4'-Azido-2'-deoxy-2'-fluoroaracytidine, reported solubility: DMSO: 57 mg/mL (199.15 mM);Ethanol: 57 mg/mL (199.15 mM). Storage: Store at -20°C.
Names and search terms
Confirmed or normalized name variants
- azvudine
- FNC
- RO 0622
- 4’-Azido-2’-deoxy-2’-fluoroaracytidine, Azvudine
- 4'-C-Azido-2'-deoxy-2'-fluoro-b-D-arabinocytidine
- 4'-C-azido-2'-deoxy-2'-fluoro-beta-D-arabinocytidine
- 2(1H)-PyriMidinone, 4-aMino-1-(4-C-azido-2-deoxy-2-fluoro-b-D-arabinofuranosyl)-
- 4-Amino-1-(4-C-azido-2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone
Useful catalog search terms
- CAS 1011529-10-4
- Nucleoside or protected nucleoside intermediate
- 2'-fluoro modification
- azide click handle
- 2'-F Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-fluoro modification; azide click handle |
|---|---|
| InChI | InChI=1/C9H11FN6O4/c10-5-6(18)9(3-17,14-15-12)20-7(5)16-2-1-4(11)13-8(16)19/h1-2,5-7,17-18H,3H2,(H2,11,13,19)/t5-,6-,7+,9+/s |
| InChIKey | KTOLOIKYVCHRJW-BODDTQOYNA-N |
| SMILES | C1(=O)N([C@H]2[C@@H](F)[C@H](O)[C@@](N=[N+]=[N-])(CO)O2)C=CC(N)=N1 |&1:3,4,6,8,r| |
| Melting point | 99.0-100.0℃ |
| Form | Solid |
| Color | White to off-white |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 4'-Azido-2'-deoxy-2'-fluoroaracytidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 4'-Azido-2'-deoxy-2'-fluoroaracytidine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2FN-0003 and CAS 1011529-10-4, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 4'-Azido-2'-deoxy-2'-fluoroaracytidine or the named structural feature represented by this product.