2'-FANA Nucleosides
5-Iodo-3',5'-bis-O-benzoyl-2'-deoxy-2'-fluoro-beta-D-arabinouridine
Quick view. We supply 5-Iodo-3',5'-bis-O-benzoyl-2'-deoxy-2'-fluoro-beta-D-arabinouridine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 97614-45-4. Catalog target purity: Specification on request.
Product profile
5-Iodo-3',5'-bis-O-benzoyl-2'-deoxy-2'-fluoro-beta-D-arabinouridine is classified as nucleoside or protected nucleoside intermediate (Formula C23H18FIN2O7; molecular weight 580.3).
5-Iodo-3',5'-bis-O-benzoyl-2'-deoxy-2'-fluoro-beta-D-arabinouridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5-Iodo-3',5'-bis-O-benzoyl-2'-deoxy-2'-fluoro-beta-D-arabinouridine, reported solubility: DMSO, Methanol. Form: Solid.
Names and search terms
Confirmed or normalized name variants
- (3xi)-3',5'-Di-O-benzoyl-2'-deoxy-2'-fluoro-5-iodouridine
- 3’,5’-Di-O-benzoylFialuridine
- 5-Iodo-3’,5’-bis-O-benzoyl-2’-deoxy-2’-fluoro-β-D-arabinouridine
- 5-iodo-1-(2'-deoxy-2'-fluoro-3',5'-di-O-benzoyl-β-D-arabinofuranosyl)uracil
Useful catalog search terms
- CAS 97614-45-4
- Nucleoside or protected nucleoside intermediate
- 2'-fluoro modification
- 2'-FANA Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-fluoro modification |
|---|---|
| InChI | InChI=1S/C23H18FIN2O7/c24-17-18(34-22(30)14-9-5-2-6-10-14)16(12-32-21(29)13-7-3-1-4-8-13)33-20(17)27-11-15(25)19(28)26-23(27)31/h1-11,16-18,20H,12H2,(H,26,28,31)/t16-,17-,18?,20-/m1/s |
| InChIKey | FBENGCVQLDKVAT-VPZFWCOMSA-N |
| SMILES | O=C(OC[C@H]1O[C@@H](n2cc(I)c(O)nc2=O)[C@H](F)C1OC(=O)c1ccccc1)c1ccccc |
| Density | 1.74±0.1 g/cm3(Predicted) |
| pKa | 7.94±0.10(Predicted) |
| Form | Solid |
| Color | White |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5-Iodo-3',5'-bis-O-benzoyl-2'-deoxy-2'-fluoro-beta-D-arabinouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5-Iodo-3',5'-bis-O-benzoyl-2'-deoxy-2'-fluoro-beta-D-arabinouridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2FAN-0088 and CAS 97614-45-4, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 5-Iodo-3',5'-bis-O-benzoyl-2'-deoxy-2'-fluoro-beta-D-arabinouridine or the named structural feature represented by this product.