2'-FANA Nucleosides
5'-O-(4,4'-Dimethoxy trityl)-2'-deoxy-2'-fluoro-5-methyl-beta-D-arabinouridine
Quick view. We supply 5'-O-(4,4'-Dimethoxy trityl)-2'-deoxy-2'-fluoro-5-methyl-beta-D-arabinouridine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 144822-48-0. Catalog target purity: Specification on request.
Product profile
5'-O-(4,4'-Dimethoxy trityl)-2'-deoxy-2'-fluoro-5-methyl-beta-D-arabinouridine is classified as nucleoside or protected nucleoside intermediate (Formula C31H31FN2O7; molecular weight 562.59).
5'-O-(4,4'-Dimethoxy trityl)-2'-deoxy-2'-fluoro-5-methyl-beta-D-arabinouridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5'-O-(4,4'-Dimethoxy trityl)-2'-deoxy-2'-fluoro-5-methyl-beta-D-arabinouridine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 1-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-2-fluoro-beta-D-arabinofuranosyl]-5-methyl-2,4(1H,3H)-pyrimidinedione
- 5′-O-(dimethoxytrityl)-2′-β-fluorothymidine
- 1-[2-FLUORO-2-DEOXY-5-O-DMTr-B-D- ARABINOFURANOSYL]-THYMINE
- 5’-O-(4,4’-Dimethoxytrityl)-2’-deoxy-2’-fluoro-5-methyl-β-Darabinouridine
Useful catalog search terms
- CAS 144822-48-0
- Nucleoside or protected nucleoside intermediate
- 2'-fluoro modification
- 2'-FANA Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-fluoro modification |
|---|---|
| InChI | InChI=1S/C31H31FN2O7/c1-19-17-34(30(37)33-28(19)36)29-26(32)27(35)25(41-29)18-40-31(20-7-5-4-6-8-20,21-9-13-23(38-2)14-10-21)22-11-15-24(39-3)16-12-22/h4-17,25-27,29,35H,18H2,1-3H3,(H,33,36,37)/t25-,26+,27-,29?/m1/s |
| InChIKey | RWIIURMGSYIIES-CRNBIQPQSA-N |
| SMILES | COc1ccc(C(OC[C@H]2OC(n3cc(C)c(O)nc3=O)[C@@H](F)[C@@H]2O)(c2ccccc2)c2ccc(OC)cc2)cc |
| Density | 1.36 |
| pKa | 9.55±0.10(Predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5'-O-(4,4'-Dimethoxy trityl)-2'-deoxy-2'-fluoro-5-methyl-beta-D-arabinouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5'-O-(4,4'-Dimethoxy trityl)-2'-deoxy-2'-fluoro-5-methyl-beta-D-arabinouridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2FAN-0021 and CAS 144822-48-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 5'-O-(4,4'-Dimethoxy trityl)-2'-deoxy-2'-fluoro-5-methyl-beta-D-arabinouridine or the named structural feature represented by this product.