DMTr-protected Nucleosides
5'-O-DMTr-2'-dG(iBu)
Quick view. We supply 5'-O-DMTr-2'-dG(iBu) as a DMTr-protected nucleoside intermediate for selective oligonucleotide building-block synthesis. CAS 68892-41-1. Catalog target purity: ≥97%.
Product profile
5'-O-DMTr-2'-dG(iBu) is classified as nucleoside or protected nucleoside intermediate (Formula C35H37N5O7; molecular weight 639.7).
5'-O-DMTr-2'-dG(iBu) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5'-O-DMTr-2'-dG(iBu), reported solubility: soluble in Methanol. Storage: −20°C.
Names and search terms
Confirmed or normalized name variants
- 5'-O-(4,4'-DIMETHOXYTRITYL)-N2-ISOBUTYRYL-2'-DEOXYGUANOSINE
- 5'-O-DIMETHOXYTRITYL-N-ISOBUTYRYL-DEOXYGUANOSINE
- DMT-DG-IBU
- DMT-N-IB-DG
- DMT-NIBU-DG
- IBU-DMT-DEOXYGUANOSINE
- N2-ISOBUTYROYL-5'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYGUANOSINE
- N2-ISOBUTYRYL-5'-(DIMETHOXYTRITYL)-2'-DEOXYGUANOSINE
Useful catalog search terms
- CAS 68892-41-1
- Nucleoside or protected nucleoside intermediate
- DMTr/DMT protection
- DMTr-protected Nucleosides
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection |
|---|---|
| Melting point | ~150 °C (dec.)(lit.) |
| Boiling point | 671.92°C (rough estimate) |
| Density | 1.2353 (rough estimate) |
| pKa | 9.16±0.20(Predicted) |
| Form | powder to crystal |
| Color | White |
| SMILES | C(OC[C@@H]1[C@@H](O)C[C@H](N2C=NC3C(=O)NC(NC(=O)C(C)C)=NC2=3)O1)(C1=CC=CC=C1)(C1C=CC(OC)=CC=1)C1=CC=C(OC)C=C1 |&1:3,4,7,r| |
| InChIKey | RMQXDNUKLIDXOS-PTIWCXHYNA-N |
| InChI | InChI=1S/C35H37N5O7/c1-21(2)32(42)38-34-37-31-30(33(43)39-34)36-20-40(31)29-18-27(41)28(47-29)19-46-35(22-8-6-5-7-9-22,23-10-14-25(44-3)15-11-23)24-12-16-26(45-4)17-13-24/h5-17,20-21,27-29,41H,18-19H2,1-4H3,(H2,37,38,39,42,43)/t27-,28+,29+/m0/s |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
- We release this product against the stated purity specification; the lot-specific CoA provides the result and analytical basis.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine can be used as fluorescent hydrogel with high intensity.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
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Frequently asked questions
Can the package size for 5'-O-DMTr-2'-dG(iBu) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0051 and CAS 68892-41-1, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry.