DMTr-protected Nucleosides
5'-O-DMTr-2'-F-dA(Bz)
Quick view. We supply 5'-O-DMTr-2'-F-dA(Bz) as a DMTr-protected 2'-fluoro nucleoside intermediate for preparing 2'-F phosphoramidites, succinates or other oligonucleotide building blocks. CAS 136834-21-4. Catalog target purity: Specification on request.
Product profile
5'-O-DMTr-2'-F-dA(Bz) is classified as nucleoside or protected nucleoside intermediate (Formula C38H34FN5O6; molecular weight 675.7).
5'-O-DMTr-2'-F-dA(Bz) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5'-O-DMTr-2'-F-dA(Bz), storage: 2-8°C. Form: Solid.
Names and search terms
Confirmed or normalized name variants
- AK-64782
- 5'-DMT-2'-F-Bz-dA
- 5'-O-DMT-N6-Bz-2'-F-dA
- 5'-O-DMT-2'-F-Benzoyl-Deoxyadenosine
- 5'-O-DMT-2'-Fluoro-N6-Benzoyl-2'-deoxyadenosine
- 5'-O-DMT-N6-BENZOYL-2'-FLUORO-2'-DEOXYADENOSINE
- N6-Benzoyl-5'-O-DMT-2'-fluoro-2'-deoxyadenosine
- N6-benzoyl-2'-deoxy-2'-fluoro-5'-O-(4,4'-dimethoxytrityl)adenosine
Useful catalog search terms
- CAS 136834-21-4
- Nucleoside or protected nucleoside intermediate
- DMTr/DMT protection
- 2'-fluoro modification
- DMTr-protected Nucleosides
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; 2'-fluoro modification |
|---|---|
| Density | 1.35±0.1 g/cm3(Predicted) |
| pKa | 7.87±0.43(Predicted) |
| Form | Solid |
| Color | White to light yellow |
| SMILES | O=C(C1C=CC=CC=1)NC1N=CN=C2C=1N=CN2[C@H]1[C@H](F)[C@H](O)[C@@H](COC(C2C=CC=CC=2)(C2C=CC(OC)=CC=2)C2C=CC(OC)=CC=2)O1 |&1:18,19,21,23,r| |
| InChIKey | DDOOVEXTSRBCMU-RDDJVILNNA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5'-O-DMTr-2'-F-dA(Bz) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5'-O-DMTr-2'-F-dA(Bz) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0064 and CAS 136834-21-4, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry.