DMTr-protected Nucleosides
5'-O-DMTr-2'-O-TBDMS-rC(Bz)
Quick view. We supply 5'-O-DMTr-2'-O-TBDMS-rC(Bz) as a benzoyl-protected cytidine intermediate for RNA phosphoramidite synthesis. CAS 81256-87-3. Catalog target purity: ≥98%.
Product profile
5'-O-DMTr-2'-O-TBDMS-rC(Bz) is classified as nucleoside or protected nucleoside intermediate (Formula C43H49N3O8Si; molecular weight 763.95).
5'-O-DMTr-2'-O-TBDMS-rC(Bz) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5'-O-DMTr-2'-O-TBDMS-rC(Bz), reported solubility: DMSO: 100 mg/mL (130.90 mM; Need ultrasonic). Storage: Sealed in dry,2-8°C.
Names and search terms
Confirmed or normalized name variants
- 5'-DMT-2'-TBDMS-Bz-rC
- 5'-O-DMT-2'-O-TBDMS-Bz-rC
- 5'-O-DMT-2'-O-TBDMS-N-Bz-Cytidine
- 2'-O-TBDMS-5'-O-DMT-N4-Bz cytidine
- N4-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-cytidine
- 2'-O-t-ButyldiMethylsilyl-5'-O-(4,4'-diMethoxytrityl)-N4-benzyl cytidine
- N-Benzoyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-2'-O-[tert-butyl(dimethyl)silyl]cytidine
- 5'-O-DMT-2'-O-TBDMS-rC(Bz)
Useful catalog search terms
- CAS 81256-87-3
- Nucleoside or protected nucleoside intermediate
- DMTr/DMT protection
- TBDMS protection
- DMTr-protected Nucleosides
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; TBDMS protection |
|---|---|
| Form | Solid |
| Color | White to light yellow |
| SMILES | O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C=CC(NC(=O)C3=CC=CC=C3)=NC2=O)[C@H](O[Si](C(C)(C)C)(C)C)[C@@H]1O |&1:25,27,44,53,r| |
| InChIKey | AOXWVTIMEGOVNF-FSGBVGTANA-N |
| InChI | InChI=1S/C43H49N3O8Si/c1-42(2,3)55(6,7)54-38-37(47)35(53-40(38)46-27-26-36(45-41(46)49)44-39(48)29-14-10-8-11-15-29)28-52-43(30-16-12-9-13-17-30,31-18-22-33(50-4)23-19-31)32-20-24-34(51-5)25-21-32/h8-27,35,37-38,40,47H,28H2,1-7H3,(H,44,45,48,49)/t35-,37-,38-,40-/m1/s |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
- We release this product against the stated purity specification; the lot-specific CoA provides the result and analytical basis.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 5'-O-DMT-2'-O-TBDMS-Bz-rC is a modified nucleoside and can be used to synthesize DNA or RNA.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
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Frequently asked questions
Can the package size for 5'-O-DMTr-2'-O-TBDMS-rC(Bz) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0044 and CAS 81256-87-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry.