DMTr-protected Nucleosides
5'-O-DMTr-2'-O-TBDMS-rU
Quick view. We supply 5'-O-DMTr-2'-O-TBDMS-rU as a standard protected uridine intermediate for RNA phosphoramidite synthesis. CAS 81246-80-2. Catalog target purity: ≥97%.
Product profile
5'-O-DMTr-2'-O-TBDMS-rU is classified as nucleoside or protected nucleoside intermediate (Formula C36H44N2O8Si; molecular weight 660.83).
5'-O-DMTr-2'-O-TBDMS-rU — 5''-O-DMT-2''-TBDMS-Uridine (cas# 81246-80-2) is a nucleoside and has been used in the prepartion of pseudorotaxane architectures. It has also been able to undergo microwave-assisted phosphitylation in the preparation of nucleoside phosphoramidites.
For 5'-O-DMTr-2'-O-TBDMS-rU, reported solubility: DMSO: 100 mg/mL (151.32 mM; Need ultrasonic). Storage: under inert gas (nitrogen or Argon) at 2-8°C.
Names and search terms
Confirmed or normalized name variants
- DMT-2'-O-TBDMS-Ur
- 5'-DMT-2'-TBDMS-rU
- 5'-O-DMT-2'-O-TBDMS-rU
- 5'-DMTr-2'-TBDMS-uridine
- 5'-O-DMT-2'-TBDMS-Uridine
- 5'-O-DMT-2'-O-TBDMS uridine
- 2'-O-TBDMS-5'-O-DMT-uridine
- 2'-O-tertButyldimethylsilyl-5'-O-DMT-uridine
Useful catalog search terms
- CAS 81246-80-2
- Nucleoside or protected nucleoside intermediate
- DMTr/DMT protection
- TBDMS protection
- DMTr-protected Nucleosides
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; TBDMS protection |
|---|---|
| Density | 1.24±0.1 g/cm3(Predicted) |
| pKa | 9.39±0.10(Predicted) |
| Form | Solid |
| Color | White to light yellow |
| SMILES | O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](O[Si](C(C)(C)C)(C)C)[C@@H]1O |&1:25,27,36,45,r| |
| InChIKey | KVHQIELPHWJPSY-WLVJKCSANA-N |
| InChI | InChI=1S/C36H44N2O8Si/c1-35(2,3)47(6,7)46-32-31(40)29(45-33(32)38-22-21-30(39)37-34(38)41)23-44-36(24-11-9-8-10-12-24,25-13-17-27(42-4)18-14-25)26-15-19-28(43-5)20-16-26/h8-22,29,31-33,40H,23H2,1-7H3,(H,37,39,41)/t29-,31-,32-,33-/m1/s |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
- We release this product against the stated purity specification; the lot-specific CoA provides the result and analytical basis.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 5'-O-DMTr-2'-O-TBDMS-rU can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
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Frequently asked questions
Can the package size for 5'-O-DMTr-2'-O-TBDMS-rU be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0046 and CAS 81246-80-2, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry.