Modified Nucleosides
8-Hydroxyadenosine
Quick view. We supply 8-Hydroxyadenosine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 29851-57-8. Catalog target purity: Specification on request.
Product profile
8-Hydroxyadenosine is classified as nucleoside or protected nucleoside intermediate (Formula C10H13N5O5; molecular weight 283.24).
8-Hydroxyadenosine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 8-Hydroxyadenosine, reported solubility: DMSO (Slightly, Sonicated), Methanol (Very Slightly, Sonicated), Water (Slightly. Storage: Refrigerator, Under inert atmosphere.
Names and search terms
Confirmed or normalized name variants
- 6-Amino-9-pentofuranosyl-9H-purin-8-ol
- 8-oxoadenosine
- 7,8-Dihydro-8-oxoadenosine
- Adenosine, 7,8-dihydro-8-oxo-
- 8-Hydroxyadenosine,, 8-Oxo-A
Useful catalog search terms
- CAS 29851-57-8
- Nucleoside or protected nucleoside intermediate
- fluorescent label
- Modified Nucleosides
Physicochemical data
| Key chemistry motifs | fluorescent label |
|---|---|
| InChI | InChI=1S/C10H13N5O5/c11-7-4-8(13-2-12-7)15(10(19)14-4)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H,14,19)(H2,11,12,13) |
| InChIKey | UEHOMUNTZPIBIL-UHFFFAOYSA-N |
| SMILES | Nc1ncnc2c1nc(O)n2C1OC(CO)C(O)C1O |
| Melting point | >228°C (dec.) |
| Form | Solid |
| Color | White to Off-White |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Fluorescent labels enable non-radioactive detection and can reduce downstream staining or secondary-label steps.
Method limitations
- Dye-labeled nucleotides or amidites are bulkier than native monomers; incorporation efficiency, label density, photobleaching and light exposure should be controlled.
These points describe 8-Hydroxyadenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 8-Hydroxyadenosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0437 and CAS 29851-57-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 8-Hydroxyadenosine or the named structural feature represented by this product.