2'-O-Me Phosphoramidites
DMTr-2'-O-Me-rC(Ac)-3'-CE-Phosphoramidite
Quick view. We supply DMTr-2'-O-Me-rC(Ac)-3'-CE-Phosphoramidite as an acetyl-protected 2'-O-methyl cytidine amidite for RNA/ASO synthesis. CAS 199593-09-4. Catalog target purity: Specification on request.
Product profile
DMTr-2'-O-Me-rC(Ac)-3'-CE-Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block (Formula C42H52N5O9P; molecular weight 801.86).
DMTr-2'-O-Me-rC(Ac)-3'-CE-Phosphoramidite — 2''-OMe-Ac-C Phosphoramidite (CAS# 199593-09-4) is a nucleotide used in the solid-phase synthesis of phosphorothioate oligonucleotides using sulfurization byproducts for in situ capping.
For DMTr-2'-O-Me-rC(Ac)-3'-CE-Phosphoramidite, reported solubility: DMSO (Slightly), Methanol (Slightly). Storage: Sealed in dry,2-8°C.
Names and search terms
Confirmed or normalized name variants
- 2'-OMe-Ac-C Phosphoramidite
- Ac-2'-Ome-rC Phosphoramidite
- 2'-OMe-C(Ac) Phosphoramidite
- 2'-OMe-Ac-rC -CE Phosphoramidite
- 5'-O-DMT-2'-O-Me-rC(N-Ac)-3'-CEDPA
- 2’-O-Methyl-rC(N-Ac)Phosphoramidite
- -5-(4-Acetamido-2-oxopyrimidin-1(2H)
- DMT-2′O-Methyl-rC(ac) Phosphoramidite
Useful catalog search terms
- CAS 199593-09-4
- Protected oligonucleotide phosphoramidite building block
- DMTr/DMT protection
- 2'-O-methyl modification
- phosphoramidite coupling group
- BX-2OMP-0049
- 2'-O-Me Phosphoramidites
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; 2'-O-methyl modification; phosphoramidite coupling group |
|---|---|
| Melting point | 102 - 104°C |
| Form | powder |
| Color | white to off-white |
| SMILES | O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C=CC(NC(C)=O)=NC2=O)[C@H](OC)[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N |&1:25,27,39,42,r| |
| InChIKey | WNWUMIPFLOKTEZ-UAQIPLLRSA-N |
| InChI | InChI=1S/C42H52N5O9P/c1-28(2)47(29(3)4)57(54-26-12-24-43)56-38-36(55-40(39(38)52-8)46-25-23-37(44-30(5)48)45-41(46)49)27-53-42(31-13-10-9-11-14-31,32-15-19-34(50-6)20-16-32)33-17-21-35(51-7)22-18-33/h9-11,13-23,25,28-29,36,38-40H,12,26-27H2,1-8H3,(H,44,45,48,49)/t36-,38-,39+,40-,57?/m1/s |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- DMTr-2'-O-Me-rC(Ac)-3'-CE-Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe DMTr-2'-O-Me-rC(Ac)-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
4'-O-CH2-phosphate methyl ester-2'-O-Me-rU-3'-CE-Phosphoramidite
2'-O-Me Phosphoramidites · CAS: 2197181-94-3
BX-2OMP-00164'-O-CH₂-phosphate monomethyl ester-2'-O-Me-rU-3'-CE-Phosphoramidite
2'-O-Me Phosphoramidites · CAS: N/A
BX-2OMP-00175'-CH₂-phosphate methyl ester-2'-O-Me-U-3'-CE-Phosphoramidite
2'-O-Me Phosphoramidites · CAS: N/A
BX-2OMP-00185'-POM-(E)-vinyl phosphonate-2'-O-Me-6-Deamino-6-(m-benzenepropanoic acid methyl ester)-rA-3'- CE-Phosphoramidite
2'-O-Me Phosphoramidites · CAS: N/A
BX-2OMP-00195'-POM-(E)-vinyl phosphonate-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite
2'-O-Me Phosphoramidites · CAS: 2419895-65-9
BX-2OMP-00205'-POM-(E)-vinyl phosphonate-2'-O-Me-rC(Bz)-3'-CE-Phosphoramidite
2'-O-Me Phosphoramidites · CAS: N/A
Frequently asked questions
Can the package size for DMTr-2'-O-Me-rC(Ac)-3'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMP-0074 and CAS 199593-09-4, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-O-Me Phosphoramidites product family and its named chemistry.