2'-O-Propargyl Phosphoramidites
DMTr-2'-O-propargyl-rC(Ac)-3' -CE-Phosphoramidite
Quick view. We supply DMTr-2'-O-propargyl-rC(Ac)-3' -CE-Phosphoramidite as a 2'-O-propargyl RNA phosphoramidite for introducing alkyne handles into oligonucleotides. CAS 1498305-51-3. Catalog target purity: ≥95%.
Product profile
DMTr-2'-O-propargyl-rC(Ac)-3' -CE-Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block (Formula C44H52N5O9P; molecular weight 825.9).
DMTr-2'-O-propargyl-rC(Ac)-3' -CE-Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
For DMTr-2'-O-propargyl-rC(Ac)-3' -CE-Phosphoramidite, copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
Names and search terms
Confirmed or normalized name variants
- DMT-2'-O-propargyl-C(Ac)-CE-Phosphoramidite
- N4-Acetyl-5'-O-DMT-2'-O-propynylcytidine 3'-CE phosphoramidite
- DMT-2'-O-propargyl-rC(Ac)-3' -CE-Phosphoramidite
- DMTr-2'-O-propargyl-rC(Ac)-3' -2-cyanoethyl phosphoramidite
- 2'-O-propargyl-C(Ac) Phosphoramidite
- BX-2OPP-0006
Useful catalog search terms
- CAS 1498305-51-3
- Protected oligonucleotide phosphoramidite building block
- DMTr/DMT protection
- alkyne click handle
- phosphoramidite coupling group
- 2'-O-Propargyl Phosphoramidites
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; alkyne click handle; phosphoramidite coupling group |
|---|
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
- We release this product against the stated purity specification; the lot-specific CoA provides the result and analytical basis.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
These points describe DMTr-2'-O-propargyl-rC(Ac)-3' -CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for DMTr-2'-O-propargyl-rC(Ac)-3' -CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OPP-0002 and CAS 1498305-51-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss DMTr-2'-O-propargyl-rC(Ac)-3' -CE-Phosphoramidite or the named structural feature represented by this product.