cEt-BNA
S-cEt-T-CE-Phosphoramidite
Quick view. We supply S-cEt-T-CE-Phosphoramidite as a constrained ethyl BNA phosphoramidite for high-affinity therapeutic oligonucleotide synthesis. CAS 1197033-22-9. Catalog target purity: Specification on request.
Product profile
S-cEt-T-CE-Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block (Formula C42H51N4O9P; molecular weight 786.86).
S-cEt-T-CE-Phosphoramidite — 5'-ODMT cEt m5U Phosphoramidite Amidite is a locked nucleic acid (LNA) analog. 5'-ODMT cEt m5U Phosphoramidite Amidite shows excellent safety and antisense activity in mice.
For S-cEt-T-CE-Phosphoramidite, form: Solid.
Names and search terms
Confirmed or normalized name variants
- S-cEt-T
- S-cEt-T phosphoramidite
- CET-5-Me-U Phosphoramidite
- 5'-ODMTcEtm5UPhosphoramiditeAmidite
- S-cEt-T-2-cyanoethyl phosphoramidite
Useful catalog search terms
- CAS 1197033-22-9
- Protected oligonucleotide phosphoramidite building block
- conformationally locked sugar
- phosphoramidite coupling group
- cEt-BNA
Physicochemical data
| Key chemistry motifs | conformationally locked sugar; phosphoramidite coupling group |
|---|---|
| InChI | InChI=1S/C42H51N4O9P/c1-27(2)46(28(3)4)56(52-24-12-23-43)55-37-36-39(45-25-29(5)38(47)44-40(45)48)54-41(37,30(6)53-36)26-51-42(31-13-10-9-11-14-31,32-15-19-34(49-7)20-16-32)33-17-21-35(50-8)22-18-33/h9-11,13-22,25,27-28,30,36-37,39H,12,24,26H2,1-8H3,(H,44,47,48)/t30-,36+,37-,39+,41-,56?/m0/s |
| InChIKey | SEFBXGXPINACNI-IMMRMUFKSA-N |
| SMILES | COc1ccc(C(OC[C@]23O[C@@H](n4cc(C)c(O)nc4=O)[C@H](O[C@H]2C)[C@@H]3OP(OCCC#N)N(C(C)C)C(C)C)(c2ccccc2)c2ccc(OC)cc2)cc |
| Form | Solid |
| Color | White to off-white |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- S-cEt-T-CE-Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- Locked/bicyclic sugar motifs can substantially increase duplex thermal stability and mismatch discrimination.
Method limitations
- High-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
These points describe S-cEt-T-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
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BX-CB-0003DMTr-S-cEt-rG(iBu)-3'-CE-Phosphoramidite
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BX-CB-0004DMTr-S-cEt-rA(Bz)-3'-CE-Phosphoramidite
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Frequently asked questions
Can the package size for S-cEt-T-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-CB-0005 and CAS 1197033-22-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss S-cEt-T-CE-Phosphoramidite or the named structural feature represented by this product.