Amino-modified Nucleosides
2-Amino-3'-O-methyladenosine
Quick view. We supply 2-Amino-3'-O-methyladenosine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 80791-88-4. Catalog target purity: Specification on request.
Product profile
2-Amino-3'-O-methyladenosine is classified as nucleoside or protected nucleoside intermediate (Formula C11H16N6O4; molecular weight 296.28).
2-Amino-3'-O-methyladenosine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2-Amino-3'-O-methyladenosine, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Confirmed or normalized name variants
- 3'-OMe-2-NH2-A
- 3'-O-Methyl-2-AMino-adenosine
- Adenosine, 2-aMino-3'-O-Methyl-
- 3'-O-Methyl-2,6-diaminopurine riboside
Useful catalog search terms
- CAS 80791-88-4
- Nucleoside or protected nucleoside intermediate
- amine functionality
- Amino-modified Nucleosides
Physicochemical data
| Key chemistry motifs | amine functionality |
|---|---|
| InChI | InChI=1S/C11H16N6O4/c1-20-7-4(2-18)21-10(6(7)19)17-3-14-5-8(12)15-11(13)16-9(5)17/h3-4,6-7,10,18-19H,2H2,1H3,(H4,12,13,15,16)/t4-,6-,7-,10-/m1/s |
| InChIKey | DKDQFJWVNWYVPR-KQYNXXCUSA-N |
| SMILES | CO[C@@H]1[C@H](O[C@H]([C@@H]1O)N2C=NC3=C(N=C(N=C32)N)N)CO |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
- 3′-O-methylation provides a defined blocked ribose terminus and is analytically distinguishable from the corresponding 2′-O-methyl isomer.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
- The 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
These points describe 2-Amino-3'-O-methyladenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2-Amino-3'-O-methyladenosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-AMN-0234 and CAS 80791-88-4, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Amino-modified Nucleosides product family and its named chemistry.