2'-O-Me Nucleosides
2'-O-Me-rU
Quick view. We supply 2'-O-Me-rU as a 2'-O-methyl uridine nucleoside for modified RNA and oligonucleotide chemistry. CAS 2140-76-3. Catalog target purity: Specification on request.
Product profile
2'-O-Me-rU is classified as nucleoside or protected nucleoside intermediate (Formula C10H14N2O6; molecular weight 258.23).
2'-O-Me-rU can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-O-Me-rU, reported solubility: DMSO (Slightly), Methanol (Slightly). Storage: Store at 0°C.
Names and search terms
Confirmed or normalized name variants
- 2'-O-METHYLURIDINE
- 2'-O-METHYLURIDINE (CHIRAL)
- 2''-O-METHYLURIDINE CRYSTALLINE
Useful catalog search terms
- CAS 2140-76-3
- Nucleoside or protected nucleoside intermediate
- 2'-O-methyl modification
- 2'-O-Me Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-O-methyl modification |
|---|---|
| Melting point | 154-156°C |
| Density | 1.53±0.1 g/cm3(Predicted) |
| pKa | 9.39±0.10(Predicted) |
| Form | Powder |
| Color | White to Off-white |
| SMILES | OC[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](OC)[C@@H]1O |
| InChI | InChI=1S/C10H14N2O6/c1-17-8-7(15)5(4-13)18-9(8)12-3-2-6(14)11-10(12)16/h2-3,5,7-9,13,15H,4H2,1H3,(H,11,14,16)/t5-,7-,8-,9-/m1/s |
| InChIKey | SXUXMRMBWZCMEN-ZOQUXTDFSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 2'-O-Me-rU or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-O-Me-rU be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0184 and CAS 2140-76-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry.