2'-O-Me Nucleosides
2'-O-Methyl-2-thiouridine
Quick view. 2'-O-Methyl-2-thiouridine is a uridine nucleoside bearing a 2'-O-methyl sugar and a 2-thio base modification, with CAS 113886-72-9. CAS 113886-72-9. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
2'-O-Methyl-2-thiouridine is classified as 2'-o-methyl-2-thiouridine nucleoside (Formula C10H14N2O5S; molecular weight 274.30).
2'-O-Methyl-2-thiouridine supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 2'-O-Methyl-2-thiouridine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 2-thio-2'-O-methyluridine
- Uridine, 2'-O-methyl-2-thio-
- s2Um
- PubChem CID 10423457
Useful catalog search terms
- CAS 113886-72-9
Physicochemical data
| IUPAC name | 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-2-sulfanylidenepyrimidin-4-one |
|---|---|
| InChI | InChI=1S/C10H14N2O5S/c1-16-8-7(15)5(4-13)17-9(8)12-3-2-6(14)11-10(12)18/h2-3,5,7-9,13,15H,4H2,1H3,(H,11,14,18)/t5-,7-,8-,9-/m1/s1 |
| InChIKey | WARUUAMZJXEUEA-ZOQUXTDFSA-N |
| SMILES | CO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=CC(=O)NC2=S)CO)O |
| Structural feature | 2'-O-methyl ribose and C2 thione |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 2'-O-Methyl-2-thiouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-O-Methyl-2-thiouridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMN-0008 and CAS 113886-72-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.