2'-O-Me Nucleosides
2'-O-Methyl-5-methylcytidine
Quick view. We supply 2'-O-Methyl-5-methylcytidine as a 2'-O-methyl nucleoside for modified RNA monomer, nucleotide and analytical standard workflows. CAS 113886-70-7. Catalog target purity: Specification on request.
Product profile
2'-O-Methyl-5-methylcytidine is classified as nucleoside or protected nucleoside intermediate (Formula C11H17N3O5; molecular weight 271.27).
2'-O-Methyl-5-methylcytidine — 5-Methyl-2’-O-methylcytidine is found in tRNAs from extremely thermophilic archaebacteria. Also, it destabilizes the triplex formation with double-stranded DNA.
For 2'-O-Methyl-5-methylcytidine, reported solubility: DMSO (Slightly), Water (Slightly, Sonicated). Storage: Refrigerator.
Names and search terms
Confirmed or normalized name variants
- 5-Methyl-2'-O-methylcytidine
- 5-Me-2'-OMe-C
- 2'-OME-5-ME-C
- 5-Me-2'-O-Me-Cr
- 5,2'-O-dimethylcytidine
- 2'-O-Methyl-5-methyl-D-cytidine
- Cytidine, 5-methyl-2'-O-methyl-
- 2'-(O-METHYL)-5-METHYLCYTIDINE USP/EP/BP
Useful catalog search terms
- CAS 113886-70-7
- Nucleoside or protected nucleoside intermediate
- 2'-O-methyl modification
- 2'-O-Me Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-O-methyl modification |
|---|---|
| InChI | InChI=1S/C11H17N3O5/c1-5-3-14(11(17)13-9(5)12)10-8(18-2)7(16)6(4-15)19-10/h,6-8,10,15-16H,4H2,1-2H3,(H2,12,13,17)/t6-,7-,8-,10-/m1/s |
| InChIKey | CNVRVGAACYEOQI-FDDDBJFASA-N |
| SMILES | CC1=CN(C(=O)N=C1N)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)OC |
| Melting point | 235-238°C |
| Boiling point | 504.6±60.0 °C(Predicted) |
| Density | 1.61±0.1 g/cm3(Predicted) |
| pKa | 13.37±0.70(Predicted) |
| Form | Solid |
| Color | White to Off-White |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 2'-O-Methyl-5-methylcytidine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 2'-O-Methyl-5-methylcytidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-O-Methyl-5-methylcytidine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMN-0007 and CAS 113886-70-7, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry.