2'-O-Me Nucleosides
2'-O-Methyl-N2-methylguanosine
Quick view. We supply 2'-O-Methyl-N2-methylguanosine as a 2'-O-methyl nucleoside for modified RNA monomer, nucleotide and analytical standard workflows. CAS 135023-21-1. Catalog target purity: Specification on request.
Structure and identity
The structure drawing for this item is being finalized. Use the CAS number and machine-readable identifiers below to confirm the requested protecting groups, stereochemistry, salt or counterion and hydration state before ordering.
CAS, molecular formula, SMILES or InChI data are shown below when available.
We withhold a drawing when a related compound, alternate salt or incompletely specified stereoisomer could be mistaken for the requested material.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
2'-O-Methyl-N2-methylguanosine is classified as nucleoside or protected nucleoside intermediate (Formula C12H17N5O5; molecular weight 311.29).
2'-O-Methyl-N2-methylguanosine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-O-Methyl-N2-methylguanosine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- Guanosine, N-methyl-2′-O-methyl-
- N2,2'-O-dimethylguanosine
- 2’-O-Methyl-N2-methylguanosine,RNA-modified nucleoside m2Gm
Useful catalog search terms
- CAS 135023-21-1
- Nucleoside or protected nucleoside intermediate
- 2'-O-methyl modification
- 2'-O-Me Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-O-methyl modification |
|---|
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 2'-O-Methyl-N2-methylguanosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-O-Methyl-N2-methylguanosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMN-0015 and CAS 135023-21-1, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry.