Protected Nucleosides
2'-O-TBDMS-5-methyluridine
Quick view. We supply 2'-O-TBDMS-5-methyluridine as a silyl-protected ribonucleoside intermediate for RNA monomer and specialty nucleoside synthesis. CAS 922508-26-7. Catalog target purity: Specification on request.
Product profile
2'-O-TBDMS-5-methyluridine is classified as nucleoside or protected nucleoside intermediate (Formula C16H28N2O6Si; molecular weight 372.49).
2'-O-TBDMS-5-methyluridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-O-TBDMS-5-methyluridine, confirm the current specification, storage conditions and downstream-method compatibility before routine use.
Names and search terms
Confirmed or normalized name variants
- 2'-O-[tert-Butyl(dimethyl)silyl]-5-methyluridine
- 2'-TBDMS-5-Me-rU
- 2'-O-TBDMS-5-Me-Ur
- 2'-O-tert-Butyldimethylsilyl-5-methyluridin
- 2'-O-[(1,1-Dimethylethyl)dimethylsilyl]-5-methyluridine
- 2'-O-tert-Butyldimethylsilyl-5-methyluridine 2'-TBDMS-5-Me-rU
Useful catalog search terms
- CAS 922508-26-7
- Nucleoside or protected nucleoside intermediate
- TBDMS protection
- Protected Nucleosides
Physicochemical data
| Key chemistry motifs | TBDMS protection |
|---|---|
| InChI | InChI=1S/C16H28N2O6Si/c1-9-7-18(15(22)17-13(9)21)14-12(11(20)10(8-19)23-14)24-25(5,6)16(2,3)4/h7,10-12,14,19-20H,8H2,1-6H3,(H,17,21,22)/t10-,11-,12-,14-/m1/s |
| InChIKey | PWAAFDSCYLYFMA-HKUMRIAESA-N |
| SMILES | CC1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O[Si](C)(C)C(C)(C)C |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
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Frequently asked questions
Can the package size for 2'-O-TBDMS-5-methyluridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0307 and CAS 922508-26-7, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Protected Nucleosides product family and its named chemistry.