3'-O-Me Nucleosides
3'-O-Me-rA
Quick view. We supply 3'-O-Me-rA as a 3'-O-methyl nucleoside for cap analog, modified RNA and protected nucleoside chemistry. CAS 10300-22-8. Catalog target purity: ≥97%.
Product profile
3'-O-Me-rA is classified as nucleoside or protected nucleoside intermediate (Formula C11H15N5O4; molecular weight 281.27).
3'-O-Me-rA can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 3'-O-Me-rA, form: Solid.
Names and search terms
Confirmed or normalized name variants
- 2H7
- 3'
- 8'
- &rarr
- 6-D6)
- -13C5
- R,5'
- -ol &ge
Useful catalog search terms
- CAS 10300-22-8
- Nucleoside or protected nucleoside intermediate
- 3'-O-Me Nucleosides
Physicochemical data
| Melting point | 177-178 °C |
|---|---|
| Boiling point | 623.8±65.0 °C(Predicted) |
| Density | 1.84±0.1 g/cm3(Predicted) |
| pKa | 12.98±0.70(Predicted) |
| Form | Solid |
| InChI | InChI=1S/C11H15N5O4/c1-19-8-5(2-17)20-11(7(8)18)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s |
| InChIKey | RYAFZRROCNNRFK-IOSLPCCCSA-N |
| SMILES | CO[C@@H]1[C@H](O[C@H]([C@@H]1O)N2C=NC3=C(N=CN=C32)N)CO |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
- We release this product against the stated purity specification; the lot-specific CoA provides the result and analytical basis.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 3′-O-methylation provides a defined blocked ribose terminus and is analytically distinguishable from the corresponding 2′-O-methyl isomer.
Method limitations
- The 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
These points describe 3'-O-Me-rA or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 3'-O-Me-rA be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-3OMN-0001 and CAS 10300-22-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 3'-O-Me Nucleosides product family and its named chemistry.