3'-O-Me Nucleosides
3'-O-Me-rG
Quick view. We supply 3'-O-Me-rG as a 3'-O-methyl guanosine nucleoside used in cap analog, modified RNA and nucleoside chemistry. CAS 10300-27-3. Catalog target purity: Specification on request.
Product profile
3'-O-Me-rG is classified as nucleoside or protected nucleoside intermediate (Formula C11H15N5O5; molecular weight 297.27).
3'-O-Me-rG can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 3'-O-Me-rG, reported solubility: DMSO: 25 mg/mL (84.10 mM; ultrasonic and warming and heat to 60°C). Storage: 4°C, stored under nitrogen.
Names and search terms
Confirmed or normalized name variants
- 3'-OMe-G
- 3'-O-Me-Gr
- Guanosine, 3'-O-methyl-
- 3'-O-methylguanosine top
- "2-AMINO-9-[3-HYDROXY-5-(HYDROXYMETHYL)-4-METHOXYOXOLAN-2-YL]-3H-PURIN-6-ONE
- 2-amino-9-[(2R,3R,4S,5R)-3-hydroxy-5-(hydroxymethyl)-4-methoxyoxolan-2-yl]-3H-purin-6-one
- 3'-O-methylguanosine
Useful catalog search terms
- CAS 10300-27-3
- Nucleoside or protected nucleoside intermediate
- 3'-O-Me Nucleosides
Physicochemical data
| Melting point | 263-300 °C (decomp) |
|---|---|
| Density | 1.98±0.1 g/cm3(Predicted) |
| Form | Solid |
| Color | White to off-white |
| SMILES | OC[C@H]1O[C@@H](N2C3=C(C(NC(=N3)N)=O)N=C2)[C@H](O)[C@@H]1OC |
| InChI | InChI=1S/C11H15N5O5/c1-20-7-4(2-17)21-10(6(7)18)16-3-13-5-8(16)14-11(12)15-9(5)19/h3-4,6-7,10,17-18H,2H2,1H3,(H3,12,14,15,19)/t4-,6-,7-,10-/m1/s |
| InChIKey | UYARPHAXAJAZLU-KQYNXXCUSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 3′-O-methylation provides a defined blocked ribose terminus and is analytically distinguishable from the corresponding 2′-O-methyl isomer.
Method limitations
- The 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
These points describe 3'-O-Me-rG or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 3'-O-Me-rG be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0157 and CAS 10300-27-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 3'-O-Me Nucleosides product family and its named chemistry.