Protected Nucleosides
3'-TBDMS-2'-O-Me-rU
Quick view. 2'-O-Methyluridine bearing a 3'-O-TBDMS group with a free 5'-hydroxyl group. CAS 171268-84-1. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
3'-TBDMS-2'-O-Me-rU is classified as protected nucleosides (Formula C16H28N2O6Si; molecular weight 372.49 g/mol).
3'-TBDMS-2'-O-Me-rU supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 3'-TBDMS-2'-O-Me-rU, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 3'-O-TBDMS-2'-O-methyluridine
- 3'-O-(tert-Butyldimethylsilyl)-2'-O-methyluridine
Useful catalog search terms
- CAS 171268-84-1
Physicochemical data
| InChIKey | VWMFRWSCFRRALN-FMKGYKFTSA-N |
|---|---|
| Nucleoside | 2'-O-Methyluridine |
| Hydroxyl protection | 3'-O-TBDMS |
| Hydroxyl state | 5' hydroxyl group unprotected |
| SMILES | CC(C)(C)[Si](C)(C)O[C@@H]1[C@H](O[C@H]([C@@H]1OC)N2C=CC(=O)NC2=O)CO |
| InChI | InChI=1S/C16H28N2O6Si/c1-16(2,3)25(5,6)24-12-10(9-19)23-14(13(12)22-4)18-8-7-11(20)17-15(18)21/h7-8,10,12-14,19H,9H2,1-6H3,(H,17,20,21)/t10-,12-,13-,14-/m1/s1 |
| PubChem CID | 66869720 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 3'-TBDMS-2'-O-Me-rU or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 3'-TBDMS-2'-O-Me-rU be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0079 and CAS 171268-84-1, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.