Protected Nucleosides
3'-TBDMS-2'-O-Me-rU
Quick view. We supply 3'-TBDMS-2'-O-Me-rU as a silyl-protected ribonucleoside intermediate for RNA monomer and specialty nucleoside synthesis. CAS 171268-84-1. Catalog target purity: Specification on request.
Product profile
3'-TBDMS-2'-O-Me-rU is classified as nucleoside or protected nucleoside intermediate (Formula C16H28N2O6Si; molecular weight 372.49).
3'-TBDMS-2'-O-Me-rU can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 3'-TBDMS-2'-O-Me-rU, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 3'-O-TBDMS-2'-OME-U
- 3'-O-TBDMS-2'-OMe-Ur
- 3'-O-(t-Butyldimethylsilyl)-2'-O-methyluridine
- 3'-O-(tert-Butyldimethylsilyl)-2'-O-methyluridine
- Uridine, 3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-O-methyl-
Useful catalog search terms
- CAS 171268-84-1
- Nucleoside or protected nucleoside intermediate
- TBDMS protection
- 2'-O-methyl modification
- Protected Nucleosides
Physicochemical data
| Key chemistry motifs | TBDMS protection; 2'-O-methyl modification |
|---|---|
| Density | 1.20±0.1 g/cm3(Predicted) |
| pKa | 9.39±0.10(Predicted) |
| SMILES | OC[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](OC)[C@@H]1O[Si](C(C)(C)C)(C)C |
| InChI | InChI=1S/C16H28N2O6Si/c1-16(2,3)25(5,6)24-12-10(9-19)23-14(13(12)22-4)18-8-7-11(20)17-15(18)21/h7-8,10,12-14,19H,9H2,1-6H3,(H,17,20,21)/t10-,12-,13-,14-/m1/s |
| InChIKey | VWMFRWSCFRRALN-FMKGYKFTSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 3'-TBDMS-2'-O-Me-rU or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 3'-TBDMS-2'-O-Me-rU be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0079 and CAS 171268-84-1, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Protected Nucleosides product family and its named chemistry.