LNA Phosphoramidites
5'-O-DMTr-LNA-5MeU-methyl phosphonamidite
Quick view. We supply 5'-O-DMTr-LNA-5MeU-methyl phosphonamidite as a specialty phosphoramidite building block for solid-phase oligonucleotide synthesis. CAS 527699-22-5. Catalog target purity: Specification on request.
Structure confirmation
This item requires structure confirmation before quotation. Send the target structure, CAS number, SMILES, InChI or drawing for our technical review.
Canonical name plus a structure drawing, SMILES, InChI or unambiguous CAS number.
Protecting groups, stereochemistry, salt or counterion, hydration and requested form.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
5'-O-DMTr-LNA-5MeU-methyl phosphonamidite is classified as protected oligonucleotide phosphoramidite building block.
5'-O-DMTr-LNA-5MeU-methyl phosphonamidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
For 5'-O-DMTr-LNA-5MeU-methyl phosphonamidite, high-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
Names and search terms
Confirmed or normalized name variants
- 5'-O-DMT-LNA-5MeU-methyl phosphonamidite
Useful catalog search terms
- CAS 527699-22-5
- Protected oligonucleotide phosphoramidite building block
- DMTr/DMT protection
- conformationally locked sugar
- phosphoramidite coupling group
- LNA Phosphoramidites
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; conformationally locked sugar; phosphoramidite coupling group |
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Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- Locked/bicyclic sugar motifs can substantially increase duplex thermal stability and mismatch discrimination.
Method limitations
- High-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
These points describe 5'-O-DMTr-LNA-5MeU-methyl phosphonamidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5'-O-DMTr-LNA-5MeU-methyl phosphonamidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-LNA-0003 and CAS 527699-22-5, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 5'-O-DMTr-LNA-5MeU-methyl phosphonamidite or the named structural feature represented by this product.