2'-O-MOE Nucleosides
N3-Methyl-2'-O-(2-methoxyethyl)uridine
Quick view. We supply N3-Methyl-2'-O-(2-methoxyethyl)uridine as a 2'-O-MOE nucleoside for antisense oligonucleotide monomer and analog synthesis. CAS 2305416-12-8. Catalog target purity: Specification on request.
Structure and identity
The structure drawing for this item is being finalized. Use the CAS number and machine-readable identifiers below to confirm the requested protecting groups, stereochemistry, salt or counterion and hydration state before ordering.
CAS, molecular formula, SMILES or InChI data are shown below when available.
We withhold a drawing when a related compound, alternate salt or incompletely specified stereoisomer could be mistaken for the requested material.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
N3-Methyl-2'-O-(2-methoxyethyl)uridine is classified as nucleoside or protected nucleoside intermediate (Formula C13H20N2O7).
N3-Methyl-2'-O-(2-methoxyethyl)uridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For N3-Methyl-2'-O-(2-methoxyethyl)uridine, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Useful catalog search terms
- CAS 2305416-12-8
- Nucleoside or protected nucleoside intermediate
- 2'-O-MOE modification
- 2'-O-MOE Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-O-MOE modification |
|---|---|
| Boiling point | 506.8±60.0 °C(Predicted) |
| Density | 1.42±0.1 g/cm3(Predicted) |
| pKa | 13.21±0.70(Predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe N3-Methyl-2'-O-(2-methoxyethyl)uridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for N3-Methyl-2'-O-(2-methoxyethyl)uridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2MOE-0014 and CAS 2305416-12-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-O-MOE Nucleosides product family and its named chemistry.