LNA Phosphoramidites
N4-Benzoyl-5'-O-(4,4'-dimethoxy trityl)-2'-O,4'-C-methylene-cytidine 3'-O-[(2-cyanoethyl) (N,N-diisopropyl)]-phosphorramidite
Quick view. We supply N4-Benzoyl-5'-O-(4,4'-dimethoxy trityl)-2'-O,4'-C-methylene-cytidine 3'-O-[(2-cyanoethyl) (N,N-diisopropyl)]-phosphorramidite as a specialty phosphoramidite building block for solid-phase oligonucleotide synthesis. CAS 206055-78-9. Catalog target purity: Specification on request.
Structure and identity
The structure drawing for this item is being finalized. Use the CAS number and machine-readable identifiers below to confirm the requested protecting groups, stereochemistry, salt or counterion and hydration state before ordering.
CAS, molecular formula, SMILES or InChI data are shown below when available.
We withhold a drawing when a related compound, alternate salt or incompletely specified stereoisomer could be mistaken for the requested material.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
N4-Benzoyl-5'-O-(4,4'-dimethoxy trityl)-2'-O,4'-C-methylene-cytidine 3'-O-[(2-cyanoethyl) (N,N-diisopropyl)]-phosphorramidite is classified as protected oligonucleotide phosphoramidite building block (Formula C47H52N5O9P; molecular weight 861.93).
N4-Benzoyl-5'-O-(4,4'-dimethoxy trityl)-2'-O,4'-C-methylene-cytidine 3'-O-[(2-cyanoethyl) (N,N-diisopropyl)]-phosphorramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
For N4-Benzoyl-5'-O-(4,4'-dimethoxy trityl)-2'-O,4'-C-methylene-cytidine 3'-O-[(2-cyanoethyl) (N,N-diisopropyl)]-phosphorramidite, high-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
Names and search terms
Confirmed or normalized name variants
- DMTr-L-C(Bz)-3-CED-phosphoramidite
- DMTr-LNA-C(Bz)-3-CED-phosphoramidite
Useful catalog search terms
- CAS 206055-78-9
- Protected oligonucleotide phosphoramidite building block
- conformationally locked sugar
- phosphoramidite coupling group
- LNA Phosphoramidites
Physicochemical data
| Key chemistry motifs | conformationally locked sugar; phosphoramidite coupling group |
|---|
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- Locked/bicyclic sugar motifs can substantially increase duplex thermal stability and mismatch discrimination.
Method limitations
- High-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
These points describe N4-Benzoyl-5'-O-(4,4'-dimethoxy trityl)-2'-O,4'-C-methylene-cytidine 3'-O-[(2-cyanoethyl) (N,N-diisopropyl)]-phosphorramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
DMTr-2'-O-4'-C-Locked- rC(Ac)-3'-CE-Phosphoramidite
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BX-LP-0002DMTr-2'-O-4'-C-Locked-5-Me-rC(Ac)-3'-CE-Phosphoramidite
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BX-LP-0003DMTr-2'-O-4'-C-Locked-5-Me-rC(Bz)-3'-CE-Phosphoramidite
LNA Phosphoramidites · CAS: 206055-82-5
BX-LP-0004DMTr-2'-O-4'-C-Locked-rA(Bz)-3'-CE-Phosphoramidite
LNA Phosphoramidites · CAS: 206055-79-0
BX-LP-0005DMTr-2'-O-4'-C-Locked-rC(Bz)-3'-CE-Phosphoramidite
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BX-LP-0006DMTr-2'-O-4'-C-Locked-rG(dmf)-3'-CE-Phosphoramidite
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Frequently asked questions
Can the package size for N4-Benzoyl-5'-O-(4,4'-dimethoxy trityl)-2'-O,4'-C-methylene-cytidine 3'-O-[(2-cyanoethyl) (N,N-diisopropyl)]-phosphorramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-LNA-0001 and CAS 206055-78-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss N4-Benzoyl-5'-O-(4,4'-dimethoxy trityl)-2'-O,4'-C-methylene-cytidine 3'-O-[(2-cyanoethyl) (N,N-diisopropyl)]-phosphorramidite or the named structural feature represented by this product.