Other Phosphoramidites
1-[(5E)-3-O-[(Bis-di-isopropyl amino)(2-cyanoethoxy) phosphino]-5,6-dideoxy-6-(diethoxyphosphinyl)-2-O-(2-methoxyethyl)-beta-D-ribo-hex-5-enofuranosyl]-5-methyluracil
Quick view. A 2-O-(2-methoxyethyl)-modified nucleoside phosphoramidite with CAS 1345562-47-1, formula C27H46N4O10P2 and molecular weight 648.62. CAS 1345562-47-1. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
![Chemical structure of 1-[(5E)-3-O-[(Bis-di-isopropyl amino)(2-cyanoethoxy) phosphino]-5,6-dideoxy-6-(diethoxyphosphinyl)-2-O-(2-methoxyethyl)-beta-D-ribo-hex-5-enofuranosyl]-5-methyluracil](/structures/9e774afca66356bc.svg)
Product profile
1-[(5E)-3-O-[(Bis-di-isopropyl amino)(2-cyanoethoxy) phosphino]-5,6-dideoxy-6-(diethoxyphosphinyl)-2-O-(2-methoxyethyl)-beta-D-ribo-hex-5-enofuranosyl]-5-methyluracil is classified as nucleoside phosphoramidite (Formula C27H46N4O10P2; molecular weight 648.62).
1-[(5E)-3-O-[(Bis-di-isopropyl amino)(2-cyanoethoxy) phosphino]-5,6-dideoxy-6-(diethoxyphosphinyl)-2-O-(2-methoxyethyl)-beta-D-ribo-hex-5-enofuranosyl]-5-methyluracil provides a reactive functional group for conjugation, immobilization or linker-extension studies.
For 1-[(5E)-3-O-[(Bis-di-isopropyl amino)(2-cyanoethoxy) phosphino]-5,6-dideoxy-6-(diethoxyphosphinyl)-2-O-(2-methoxyethyl)-beta-D-ribo-hex-5-enofuranosyl]-5-methyluracil, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Useful catalog search terms
- CAS 1345562-47-1
- C27H46N4O10P2
- 2-O-(2-methoxyethyl) nucleoside phosphoramidite
Physicochemical data
| Sugar modification | 2-O-(2-methoxyethyl) |
|---|---|
| Phosphorus features | 3-O phosphino and 6-diethoxyphosphinyl groups as named |
| Alkene descriptor | (5E) |
| PubChem CID | 171361617 |
| InChIKey | ZKWFXIYADJXBPV-VCTZGUFNSA-N |
| InChI | InChI=1S/C27H46N4O10P2/c1-9-38-43(34,39-10-2)17-12-22-23(41-42(37-14-11-13-28)31(19(3)4)20(5)6)24(36-16-15-35-8)26(40-22)30-18-21(7)25(32)29-27(30)33/h12,17-20,22-24,26H,9-11,14-16H2,1-8H3,(H,29,32,33)/b17-12+/t22-,23-,24-,26-,42?/m1/s1 |
| SMILES | CCOP(=O)(/C=C/[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=C(C(=O)NC2=O)C)OCCOC)OP(N(C(C)C)C(C)C)OCCC#N)OCC |
| Canonical SMILES | CCOP(=O)(/C=C/[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=C(C(=O)NC2=O)C)OCCOC)OP(N(C(C)C)C(C)C)OCCC#N)OCC |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 1-[(5E)-3-O-[(Bis-di-isopropyl amino)(2-cyanoethoxy) phosphino]-5,6-dideoxy-6-(diethoxyphosphinyl)-2-O-(2-methoxyethyl)-beta-D-ribo-hex-5-enofuranosyl]-5-methyluracil or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 1-[(5E)-3-O-[(Bis-di-isopropyl amino)(2-cyanoethoxy) phosphino]-5,6-dideoxy-6-(diethoxyphosphinyl)-2-O-(2-methoxyethyl)-beta-D-ribo-hex-5-enofuranosyl]-5-methyluracil be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-OP-0157 and CAS 1345562-47-1, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Other Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.