Modified Nucleosides
2',5'-Dideoxyuridine
Quick view. We supply 2',5'-Dideoxyuridine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 35959-50-3. Catalog target purity: Specification on request.
Product profile
2',5'-Dideoxyuridine is classified as nucleoside or protected nucleoside intermediate (Formula C9H12N2O4; molecular weight 212.204).
2',5'-Dideoxyuridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2',5'-Dideoxyuridine, reported solubility: DMSO (Slightly), Methanol (Slightly). Form: Low-Melting Solid.
Names and search terms
Confirmed or normalized name variants
- 1-[(2R,4S,5R)-4-hydroxy-5-methyloxolan-2-yl]pyrimidine-2,4-dione
- Uridine, 2',5'-dideoxy-
Useful catalog search terms
- CAS 35959-50-3
- Nucleoside or protected nucleoside intermediate
- Modified Nucleosides
Physicochemical data
| InChI | InChI=1S/C9H12N2O4/c1-5-6(12)4-8(15-5)11-3-2-7(13)10-9(11)14/h2-3,5-6,8,12H,4H2,1H3,(H,10,13,14)/t5-,6+,8-/m1/s |
|---|---|
| InChIKey | FDCFKLBIAIKUKB-GKROBHDKSA-N |
| SMILES | C[C@@H]1[C@H](C[C@@H](O1)N2C=CC(=O)NC2=O)O |
| Form | Low-Melting Solid |
| Color | White to Off-White |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
These points describe 2',5'-Dideoxyuridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2',5'-Dideoxyuridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0493 and CAS 35959-50-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry.