Reverse Phosphoramidites
2'-F-dG(iBu)-CE-Reverse Phosphoramidite
Quick view. 2'-F-dG(iBu)-CE-Reverse Phosphoramidite is a protected 2'-fluoro guanosine building block with 3'-O-DMTr protection, an N2-isobutyryl group and a 5'-cyanoethyl N,N-diisopropyl phosphoramidite. The reviewed identity corresponds to PubChem CID 169074193. CAS 2757763-07-6. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
2'-F-dG(iBu)-CE-Reverse Phosphoramidite is classified as protected 2'-fluoro purine nucleoside reverse phosphoramidite (Formula C44H53FN7O8P; molecular weight 857.91).
2'-F-dG(iBu)-CE-Reverse Phosphoramidite is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 2'-F-dG(iBu)-CE-Reverse Phosphoramidite, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 3'-O-DMTr-2'-F-dG(iBu)-5'-CE-Phosphoramidite
- 3'-DMT-2'-F-dG(iBu)-CE Reverse
Useful catalog search terms
- CAS 2757763-07-6
- Reverse Phosphoramidites
Physicochemical data
| PubChem CID | 169074193 |
|---|---|
| InChIKey | LWQNQPOOAQJXAZ-AOCJBPQJSA-N |
| Structural features | 3'-O-DMTr; 2'-fluoro; N2-isobutyryl guanine; 5'-cyanoethyl N,N-diisopropyl phosphoramidite |
| InChI | InChI=1S/C44H53FN7O8P/c1-27(2)40(53)49-43-48-39-37(41(54)50-43)47-26-51(39)42-36(45)38(35(59-42)25-58-61(57-24-12-23-46)52(28(3)4)29(5)6)60-44(30-13-10-9-11-14-30,31-15-19-33(55-7)20-16-31)32-17-21-34(56-8)22-18-32/h9-11,13-22,26-29,35-36,38,42H,12,24-25H2,1-8H3,(H2,48,49,50,53,54)/t35-,36-,38-,42-,61?/m1/s1 |
| SMILES | CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)COP(N(C(C)C)C(C)C)OCCC#N)OC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)F |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2'-F-dG(iBu)-CE-Reverse Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
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BX-RP-00033'-O-DMTr-2'-O-MOE-rA(Bz)-5'-CE-Phosphoramidite
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BX-RP-00043'-O-DMTr-2'-O-MOE-rG(iBu)-5'-CE-Phosphoramidite
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BX-RP-00063'-O-DMTr-2'-O-Me-rU-5'-CE-Phosphoramidite
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BX-RP-00073'-O-DMTr-2'-dG(dmf)-5'-CE-Phosphoramidite
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Frequently asked questions
Can the package size for 2'-F-dG(iBu)-CE-Reverse Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-RP-0016 and CAS 2757763-07-6, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Reverse Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.