2'-Fluoro Phosphoramidites
2'-fluoro-5MeC (Bz)-3'-phosphoramidite
Quick view. We supply 2'-fluoro-5MeC (Bz)-3'-phosphoramidite as a specialty phosphoramidite building block for solid-phase oligonucleotide synthesis. CAS 182495-83-6. Catalog target purity: Specification on request.
Structure and identity
The structure drawing for this item is being finalized. Use the CAS number and machine-readable identifiers below to confirm the requested protecting groups, stereochemistry, salt or counterion and hydration state before ordering.
CAS, molecular formula, SMILES or InChI data are shown below when available.
We withhold a drawing when a related compound, alternate salt or incompletely specified stereoisomer could be mistaken for the requested material.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
2'-fluoro-5MeC (Bz)-3'-phosphoramidite is classified as protected oligonucleotide phosphoramidite building block (Formula C47H53FN5O8P; molecular weight 865.94).
2'-fluoro-5MeC (Bz)-3'-phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
For 2'-fluoro-5MeC (Bz)-3'-phosphoramidite, reported solubility: DMSO: Sparingly Soluble: 1-10 mg/ml Ethanol: Sparingly Soluble: 1-10 mg/ml.
Names and search terms
Confirmed or normalized name variants
- DMT-2'-F-dC(Bz)-CE-Phosphoramidite
- N-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluoro-5-methylcytidine 3'-CE phosphoramidite
- N4-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluoro-5-methylcytidine 3'-CE phosphoramidite
Useful catalog search terms
- CAS 182495-83-6
- Protected oligonucleotide phosphoramidite building block
- 2'-fluoro modification
- phosphoramidite coupling group
- 2'-Fluoro Phosphoramidites
Physicochemical data
| Key chemistry motifs | 2'-fluoro modification; phosphoramidite coupling group |
|---|
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2'-fluoro-5MeC (Bz)-3'-phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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BX-2FP-0004DMTr-2'-F-dC(Bz)-3'-(L)-DPSE-Phosphoramidite
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BX-2FP-0005DMTr-2'-F-dG(dmf)-3'-(L)-PSM-Phosphoramidite
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BX-2FP-0006DMTr-2'-F-dG(dmf)-3'-CE-Phosphoramidite
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Frequently asked questions
Can the package size for 2'-fluoro-5MeC (Bz)-3'-phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2FP-0032 and CAS 182495-83-6, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-Fluoro Phosphoramidites product family and its named chemistry.