Modified Nucleotides
2'-O-4'-C-Locked-GMP TEA Salt
Quick view. A triethylammonium salt of LNA-GMP, with a 2'-O,4'-C methylene bridge in the sugar and a 5'-monophosphate group. CAS 1152762-58-7. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
2'-O-4'-C-Locked-GMP TEA Salt is classified as modified nucleotides.
2'-O-4'-C-Locked-GMP TEA Salt is useful for high-affinity probes, SNP/mismatch-discrimination studies, antisense designs and short sequence probes.
For 2'-O-4'-C-Locked-GMP TEA Salt, high-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
Names and search terms
Confirmed or normalized name variants
- LNA-GMP TEA Salt
- 2'-O,4'-C-Methylene-5'-guanylic acid TEA Salt
- 2'-O-4'-C-Locked-GMP triethylammonium salt
Useful catalog search terms
- CAS 1152762-58-7
Physicochemical data
| CAS basis | Related free-acid LNA-GMP identity |
|---|---|
| Free-acid molecular formula | C11H14N5O8P |
| Free-acid molecular weight | 375.23 |
| Salt form | Triethylammonium (TEA) salt |
| Counterion stoichiometry | Not specified |
| Sugar modification | 2'-O,4'-C methylene bridge |
| Phosphate state | 5'-monophosphate |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Locked/bicyclic sugar motifs can substantially increase duplex thermal stability and mismatch discrimination.
Method limitations
- High-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
These points describe 2'-O-4'-C-Locked-GMP TEA Salt or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-O-4'-C-Locked-GMP TEA Salt be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0029 and CAS 1152762-58-7, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact BX Lab product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.