Base-protected Nucleosides
2'-O-4'-C-Locked-rG(iBu)
Quick view. We supply 2'-O-4'-C-Locked-rG(iBu) as an isobutyryl-protected LNA guanosine intermediate for locked guanine phosphoramidite preparation. CAS 206055-68-7. Catalog target purity: ≥98%.
Product profile
2'-O-4'-C-Locked-rG(iBu) is classified as nucleoside or protected nucleoside intermediate (Formula C15H19N5O6; molecular weight 365.34).
2'-O-4'-C-Locked-rG(iBu) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-O-4'-C-Locked-rG(iBu), high-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
Names and search terms
Confirmed or normalized name variants
- N2-Isobutyryl-2'-O,4'-C-methyleneguanosine
- Guanosine, 2'-O,4'-C-methylene-N-(2-methyl-1-oxopropyl)- (9CI)
Useful catalog search terms
- CAS 206055-68-7
- Nucleoside or protected nucleoside intermediate
- conformationally locked sugar
- Base-protected Nucleosides
Physicochemical data
| Key chemistry motifs | conformationally locked sugar |
|---|
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
- We release this product against the stated purity specification; the lot-specific CoA provides the result and analytical basis.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Locked/bicyclic sugar motifs can substantially increase duplex thermal stability and mismatch discrimination.
Method limitations
- High-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
These points describe 2'-O-4'-C-Locked-rG(iBu) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-O-4'-C-Locked-rG(iBu) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0009 and CAS 206055-68-7, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 2'-O-4'-C-Locked-rG(iBu) or the named structural feature represented by this product.