2'-O-Me Nucleosides
N6,2'-O-Dimethyladenosine
Quick view. An N6,2'-O-dimethyladenosine nucleoside building block for nucleoside and oligonucleotide synthesis research. CAS 57817-83-1. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
N6,2'-O-Dimethyladenosine is classified as 2'-o-me nucleosides (Formula C12H17N5O4; molecular weight 295.30).
N6,2'-O-Dimethyladenosine — Modified adenosine nucleoside building block for nucleoside and oligonucleotide synthesis research.
For N6,2'-O-Dimethyladenosine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 2'-O-Me-N6-Me-rA
- m6Am
- 2'-O-methyl-N6-methyladenosine
Useful catalog search terms
- CAS 57817-83-1
Physicochemical data
| InChIKey | GRYSXUXXBDSYRT-WOUKDFQISA-N |
|---|---|
| Nucleobase modification | N6-methyl |
| Sugar modification | 2'-O-methyl |
| InChI | InChI=1S/C12H17N5O4/c1-13-10-7-11(15-4-14-10)17(5-16-7)12-9(20-2)8(19)6(3-18)21-12/h4-6,8-9,12,18-19H,3H2,1-2H3,(H,13,14,15)/t6-,8-,9-,12-/m1/s1 |
| SMILES | CNC1=C2C(=NC=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)OC |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe N6,2'-O-Dimethyladenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for N6,2'-O-Dimethyladenosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMN-0004 and CAS 57817-83-1, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.